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Microsoft word - tissue oxygen measurement reference list

Tissue Oxygen Measurement Reference List
1.1 Anesthesiology
Ranjan S, Thomson S, Tuccillo ML, Addei A, Hagger R, Rahman T, Al-Subaie N, Hamilton M, "Anaesthesia induced changes in tissue saturation in response to vascular occlusion test," Intensive Care Medicine, 2009;35(Suppl 1):S157. Dagois S, Damoisel C, Lukaszewicz AC, Vostroknoutova I, Gevorgyan H, Luengo C, Pocard M, Payen D, "Is there any difference between general anesthesia alone or associated with thoracic epidural anaesthesia on thenar StO2 along hyperthermia for intraperitoneal chemotherapy?," Intensive Care Medicine, 2009;35(Suppl 1):S155 Dagois S, Caragliano G, Heyer L, Vostroknoutova I, Gevorgyan H, Luengo C, Pocard M and Payen D, "Consequences of hyperthermic intraperitoneal chemotherapy on systemic and tissue perfusion (thenar eminence): during general anaesthesia associated or not with thoracic epidural anaesthesia," Intensive Care Medicine, 2008;34(Supp 1):S257. Abstract 1008. M.P. Buise, C. Ince, H.W. Tilanus, J. Klein, D. Gommers, and J. van Bommel, "The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction," Anesthesia and Analgesia, vol. 100, Apr. 2005, pp. 1107-1111. 1.2 Angiology and Wound Healing
Functions of microvascular circulation can be estimated by monitoring local tissue oxygen saturation. This can be achieved either continuously monitoring the gastrointestinal, liver or muscle tissues, or recording the dynamic responses during vascular occlusion tests. 1.2.1 Gastrointestinal
L.A. Schwarte, A. Fournell, J. van Bommel, and C. Ince, "Redistribution of intestinal microcirculatory oxygenation during acute hemodilution in pigs," Journal of Applied Physiology (Bethesda, Md.: 1985), vol. 98, Mar. 2005, pp. 1070-1075. M.P. Buise, C. Ince, H.W. Tilanus, J. Klein, D. Gommers, and J. van Bommel, "The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction," Anesthesia and Analgesia, vol. 100, Apr. 2005, pp. 1107-1111. A. Pittner, M. Nalos, P. Asfar, Y. Yang, C. Ince, M. Georgieff, U.B. Brückner, P. Radermacher, and G. Fröba, "Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia," Intensive Care Medicine, vol. 29, Feb. 2003, pp. 312-316. B. Brell, B. Temmesfeld-Wollbrück, I. Altzschner, E. Frisch, B. Schmeck, A.C. Hocke, N. Suttorp, and S. Hippenstiel, "Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage," Critical Care Medicine, vol. 33, Apr. 2005, pp. 819-826. E.S. Lee, A. Bass, F.R. Arko, M. Heikkinen, E.J. Harris, C.K. Zarins, P. van der Starre, and C. Olcott, "Intraoperative Colon Mucosal Oxygen Saturation During Aortic Surgery," Journal of Surgical Research, vol. 136, Nov. 2006, pp. 19-24. D.V. Noord, P. Pattynama, H.J. Verhagen, E.J. Kuipers, and P. Mensink, "Endoscopic Visible Light Spectroscopy: A New Minimally Invasive Technique for the Diagnosis of Chronic Gastrointestinal Ischemia," Gastroenterology, vol. 136, 2009, pp. A-775-A-775. SL Wang, DY Sze, MD Dake, S Friedland, DA Benaron, and MK Razavi, "Continuous gastrointestinal mucosal oximetry during endovascular procedures carrying risk of ischemia," Proceedings of the 2004 SIR Annual Scientific Meeting Conference, Phoenix AZ March 30 – April 1, 2004 1.2.2 Liver
C. Wunder, R. Brock, A. Krug, N. Roewer, and O. Eichelbronner, "A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation," Comparative Hepatology, vol. 4, 2005, p. 1. A. Brinkmann, E. Calzia, K. Träger, and P. Radermacher, "Monitoring the hepato-splanchnic region in the critically ill patient. Measurement techniques and clinical relevance," Intensive Care Medicine, vol. 24, Jun. 1998, pp. 542-556. P. Dutkowski, A. Krug, F. Dünschede, S. Westermann, Th. Junginger, "Hypothermic Oxygenation of The Rat Liver After Cold Storage Prevents Reperfusion Injury," Proceedings of the 6th World Congress on Trauma, Shock, Inflammation and Sepsis--Pathophysiology, Immune Consequences and Therapy, Munich, Germany, March 2-6, 2004 1.2.3 Muscle
S.J. Thomson, M.L. Cowan, D.M. Forton, S.J. Clark, S. Musa, M. Grounds, and T.M. Rahman, "A study of muscle tissue oxygenation and peripheral microcirculatory dysfunction in cirrhosis using near infrared spectroscopy," Liver International: Official Journal of the International Association for the Study of the Liver, vol. 30, Mar. 2010, pp. 463-471. V. Gerovasili, E. Tripodaki, E. Karatzanos, T. Pitsolis, V. Markaki, D. Zervakis, C. Routsi, C. Roussos, and S. Nanas, "Short-term systemic effect of electrical muscle stimulation in critically ill patients," Chest, vol. 136, Nov. 2009, pp. 1249-1256. L. Heyer, A. Mebazaa, E. Gayat, M. Resche-Rigon, C. Rabuel, E. Rezlan, A. Lukascewicz, C. Madadaki, R. Pirracchio, P. Schurando, O. Morel, Y. Fargeaudou, and D. Payen, "Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S8. K.C. Doerschug, A.S. Delsing, G.A. Schmidt, and W.G. Haynes, "Impairments in microvascular reactivity are related to organ failure in human sepsis," American Journal of Physiology. Heart and Circulatory Physiology, vol. 293, Aug. 2007, pp. H1065-1071. S. Nanas, V. Gerovasili, P. Renieris, E. Angelopoulos, M. Poriazi, K. Kritikos, A. Siafaka, I. Baraboutis, D. Zervakis, V. Markaki, C. Routsi, and C. Roussos, "Non-invasive assessment of the microcirculation in critically ill patients," Anaesthesia and Intensive Care, vol. 37, Sep. 2009, pp. 733-739. S. Nanas, V. Gerovasili, S. Dimopoulos, C. Pierrakos, S. Kourtidou, E. Kaldara, S. Sarafoglou, J. Venetsanakos, C. Roussos, J. Nanas, and M. Anastasiou-Nana, "Inotropic agents improve the peripheral microcirculation of patients with end-stage chronic heart failure," Journal of Cardiac Failure, vol. 14, Jun. 2008, pp. 400-406. V. Gerovasili, C. Pierakos, S. Dimopoulos, E. Kaldara, S. Kourtidou, S. Sarafoglou, M. Kravari, J. Venetsanakos, G. Tzanis, and S. Nanas, "Muscle microcirculation alterations increase with disease severity in chronic heart failure patients," Critical Care, vol. 11, 2007, p. P263. S. Nanas, P. Renieris, V. Gerovasili, M. Poriazi, K. Kritikos, E. Aggelopoulos, S. Kolias, D. Zervakis, C. Routsi, and C. Roussos, "Non-invasive assessment of the microcirculation in ICU patients," Critical Care, vol. 10, 2006, p. P318. Pareznik, R. Knezevic, G. Voga, and M. Podbregar, "Changes in muscle tissue oxygenation during stagnant ischemia in septic patients," Intensive Care Medicine, vol. 32, Jan. 2006, pp. 87-92. Thooft A, Favory R, Salgado DR, De Backer D, Vincent JL, Creteur J, "Effects of increasing mean arterial pressure with norepinephrine on microvascular reactivity in septic shock patients," Intensive Care Medicine, 2009;35(Suppl 1):S80 Mesquida J, Baigorri F, Masip J, Martinez ML, Gruartmoner G and Artigas A, "Thenar oxygen saturation (StO2) and invasive oxygen delivery measurements in patients with cardiovascular insufficiency what are we measuring?,"Intensive Care Medicine, 2009;35(Suppl 1):S81. Creteur J, Neves AP, Ospina G, De Backer D, Vincent JL, "Muscle oxygen consumption is related to the degree of microvascular dysfunction in patients with severe sepsis," Intensive Care Medicine, 2009;35(Suppl 1):S104 Cavazzuti I, Rinaldi L, Braccini MS, Bertolotti V, Andreotti A, Busani S, Girardis M, "Effects of intravenous IGM-enriched immunoglobulins on muscle tissue mircrocirculation in septic shock: a preliminary report," Intensive Care Medicine, 2009;35(Suppl 1):S239 Simon P, Mesquida J, Suffoletto B, Gomez H, Kellum J and Pinsky M, "Effect of pharmacologic vasodilation on skeletal muscle oxygen extraction," Critical Care Medicine, 2009;37(12, Suppl):A88. Donati A, Romanelli M, Romagnoli L, Botticelli L, Anastasi C and Pelaia P, "Microcirculatory changes after activated protein-C infusion in severe sepsis," Intensive Care Medicine, 2008;34(Supp 1):S104. Abstract 0395. Georger JF, Chaari A, Richard C and Teboul JL, "Effects of fluid resuscitation on microcirculation assessed by near infrared spectroscopy in septic patients," Intensive Care Medicine, 2008;34(Supp 1):S66. Abstract 0247. Nanou V, Armeniakou E, Gerovasili V, Tasoulis A, Perpati G, Leontis M, Tzanis G, Roussos Ch, Nanas S and Pouliou E, "Near infrared spectroscopy (NIRS) and muscle metabolic defect during early recovery from maximal exercise in patients with cystic fibrosis (CF)," American Journal of Respiratory and Critical Care Medicine, 2008;177(Abstracts Issue):A456. Strahovnik I, Podbregar M, "Measurement of skeletal muscle tissue oxygenation in the critically ill," Signa Vitae, 2008;3(1):43-50. Rinaldi L, Busani S and Girardis M, "Muscle tissue oxygenation in septic patients treated with activated protein C," Intensive Care Medicine, 2006;32(Supp 1):S178. Abstract 0681. Payen D, Heyer L, Damoisel C, Kerever S, Luengo C and Losser MR, "Assessment by StO2 of peripheral tissue perfusion improvement with activated protein C (APC) in human septic shock," Critical Care Medicine, 2007;35(12, Abstract Supplement):A279. Abstract 1005. Sales Jr J, Buchele GL, Ospina GA, Creteur J and Vincent JL, "Effects of activated protein C on the microvascular response to reactive hyperemia in patients with septic shock," Intensive Care Medicine, 2006;32(Supp 1):S290. Abstract 1125. Pujol W, Vargas F, Bui HN, Clouzeau B, Herpe B, Medrano J, Garnier S, Boyer A, Pillet O, Gruson D, Hilbert G, Gbikpi-Benissan G and Castaing Y, "Skeletal muscle dynamic near-infraread spectroscopy measurements in patients with septic shock," Critical Care Medicine, 2007;35(12, Abstract Supplement):A77. Abstract 293. Borrat X, Sanchez-Etayo G, Mercadal J, Tercero F, De la Riba N, Israel T, Adalia R and Zabala E, "NIRS assessment of microcirculation in septic and polytraumatized patients," Intensive Care Medicine, 2006;32(Supp 1):S172. Abstract 0657. Creteur J, Buchele G, Sales Jr J, Ospina G and Vincent J, "Muscle oxygen consumption is decreased in septic patients," Intensive Care Medicine, 2006;32(Supp 1):S290. Abstract 1126. Heyer L, Madadaki C, Rezlan E, Welschbillig S, Mateo J and Payen D, "Differential micro-oxygenation dysfunction in haemorrhagic and septic shock patients," Intensive Care Medicine, 2006;32(Supp 1):S254. Abstract 0982 Mozina H, Strahovnik I and Podbregar M, "Muscle oxygenation in low flow state and sepsis: correlation to hemodynamics and outcome," Intensive Care Medicine, 2006;32(Supp 1):S290. Abstract 1128. Renieris P, Gerovasili V, Poriazi M, Loukas T, Markaki V, Routsi C, Roussos C and Nanas S, "Microcirculatory dysfunction in ICU patients with sepsis," Intensive Care Medicine, 2006;32(Supp 1):S98. Abstract 0371. Pareznick R, Voga G, Knezevic R and Podbregar M, "Improvement of muscle tissue deoxygenation during stagnant ischemia in survivors of severe sepsis," Intensive Care Medicine, 2004;30(Supp 1):S144. Abstract 554. 1.2.4 Vascular Occlusion
E. Futier, B. Vallet, E. Robin, M. Vignaud, J. Constantin, and J. Bazin, "Use of near-infrared spectroscopy during a vascular occlusion test to assess the microcirculatory response during fluid responsiveness," Critical Care, vol. 14, 2010, p. P152. S.J. Thomson, M.L. Cowan, S. Musa, N. Al-Subaie, M. Hamilton, M. Grounds, and T.M. Rahman, "Exaggerated StO2 hyperaemic response to vascular occlusion testing in cirrhosis using near infrared spectroscopy," Journal of Hepatology, vol. 50, Apr. 2009, p. S282. A. Donati, M. Romanelli, L. Botticelli, A. Valentini, V. Gabbanelli, S. Nataloni, T. Principi, P. Pelaia, R. Bezemer, and C. Ince, "Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S12. D. Payen, C. Luengo, L. Heyer, M. Resche-Rigon, S. Kerever, C. Damoisel, and M.R. Losser, "Is thenar tissue hemoglobin oxygen saturation in septic shock related to macrohemodynamic variables and outcome?," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S6. V. Gerovasili, S. Dimopoulos, G. Tzanis, M. Anastasiou-Nana, and S. Nanas, "Utilizing the vascular occlusion technique with NIRS technology," International Journal of Industrial Ergonomics, vol. 40, Mar. 2010, pp. 218-222. Al-Subaie N, Ranjan S, Thomson S, Tuccillo ML, Addei A, Hagger R, Hamilton M, Rhodes A, "Tissue oxygen saturation (StO2) in patients undergoing major bowel surgery predicts post operative complications," Intensive Care Medicine, 2009;35(Suppl 1):S157. Sherwin R, Mango L, Medado P and Levy P, "Describing global and tissue level perfusion in congestive heart failure patients presenting to an urban emergency department: a pilot study," Annals of Emergency Medicine, 2009;54(Suppl 3):S59 Siebig S, Wiest R, Bruennler T and Wrede C, "Microcirculatory dysfunction in ICU patients with decompensated liver cirrhosis measured by near-infrared spectroscopy," Critical Care Medicine, 2009;37(12,suppl):A359. Guyette F, Gomez H, Suffoletto B, Quintero J, Mesquida J, Kim HK, Hostler D, Puyana J and Pinsky M, "Prehospital dynamic tissue O2 saturation response predicts in-hospital mortality in trauma patients," Critical Care Medicine, 2009;37(12, Suppl):A28. Pottecher J, Mathe O, Laplace C, Mesnil M, Repesse X, Benhamou D and Duranteau, J, "Microvascular dysfunction in trauma hemorrhagic shock : Assessment with near infrare specetroscopy during occlusion tests," Intensive Care Medicine, 2008;34(1):S257. Abstract 1007. Georger JF, Chaari A, Richard C and Teboul JL, "Can near infrared spectroscopy detect functional microcirculation abnormalities in septic patients?," Intensive Care Medicine, 2007;33(Supp 2):S254. Abstract 0987. Georger JF, Chaari A, Richard C and Teboul JL, "Effects of norepinephrine on regional perfusion assessed by near infrared spectroscopy in patients with septic shock," Intensive Care Medicine, 2007;33(Supp 2):S166. Abstract 0641 Payen D, Damoisel C, Heyer L, Luengo C, Kerever S and Losser MR, "Evaluation of thenar hemoglobin oxygen saturation (StO2) items as outcome markers at day 0 of human septic shock," Critical Care Medicine, 2007;35(12, Abstract Supplement):A271. Abstract 975. Heyer L, Rezlan E, Madadaki K, Rabuel C, Schourando P and Payen D, "Diffuse micro-oxygenation impairment in acute haemorragic shock," Intensive Care Medicine, 2006;32(Supp 1):S168. Abstract 0643 Heyer L, Madadaki K, Rezlan E, Mateo J, Losser MR and Payen D, "Impact of time on systemic and local evaluation of perfusion/oxygenation during septic shock," Intensive Care Medicine, 2005;31(Supp 1):S16. Abstract 044. Al-Subaie N, Ranjan S, Thomson S, Tuccillo ML, Addei A, Hagger R, Hamilton M, Rhodes A, "Tissue oxygen saturation (StO2) in patients undergoing major bowel surgery predicts post operative complications," Intensive Care Medicine, 2009;35(Suppl 1):S157. 1.2.5 General
D. Scholz, T. Ziegelhoeffer, A. Helisch, S. Wagner, C. Friedrich, T. Podzuweit, and W. Schaper, "Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice," Journal of Molecular and Cellular Cardiology, vol. 34, Jul. 2002, pp. 775-787. A. Teymoortash, A. Sesterhenn, R. Kress, N. Sapundzhiev, and J.A. Werner, "Efficacy of ice packs in the management of epistaxis," Clinical Otolaryngology and Allied Sciences, vol. 28, Dec. 2003, pp. 545-547. J. Hoper and L. Plasswilm, "Micro-Light Guide Spectrophotometric Measurement of Changes in Local Haemoglobin Oxygenation and Concentration in the Rabbit Lung Induced by Hypoxia and Hyperoxia," International Journal of Microcirculation, vol. 14, 1994, pp. 282-288. V. Gerovasili, S. Drakos, M. Kravari, K. Malliaras, E. Karatzanos, S. Dimopoulos, A. Tasoulis, M. Anastasiou-Nana, C. Roussos, and S. Nanas, "Physical exercise improves the peripheral microcirculation of patients with chronic heart failure," Journal of Cardiopulmonary Rehabilitation and Prevention, vol. 29, Dec. 2009, pp. 385-391. A. Lima, J. van Bommel, T.C. Jansen, C. Ince, and J. Bakker, "Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S13. J. Creteur, A.P. Neves, and J. Vincent, "Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S11. A. Donati, L. Botticelli, C. Anastasi, M. Romanelli, L. Romagnoli, V. Beato, and P. Pelaia, "Tissue perfusion evaluation with near-infrared spectroscopy during treatment with activated protein C," Critical Care, vol. 12, 2008, p. P67. A. Draisma, R. Bemelmans, J.G. van der Hoeven, P. Spronk, and P. Pickkers, "Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans," Shock (Augusta, Ga.), vol. 31, Jun. 2009, pp. 581-585. M. Meznar, R. Pareznik, and G. Voga, "Tissue oxygen saturation and the rate of tissue deoxygenation during stagnant ischemia in the medical emergency department," Critical Care, vol. 11, 2007, p. P274. P. Polanco, A. Torres, H. Kim, M. Rosengart, M. Pinsky, and J. Puyana, "Sublingual pCO2 as a marker of progressive tissue dysfunction and mortality in a model of circulatory collapse in severe hemorrhage," Journal of Surgical Research, vol. 130, 2006, pp. 279-280. Coerper S., Beckert S. and Beckert H. D., "New method for measurement of ischemia in wounds - a pilot study," Proceedings of the 6th World Congress on Trauma, Shock, Inflammation and Sepsis--Pathophysiology, Immune Consequences and Therapy, Munich, Germany, March 2-6, 2004 Ferrandiere M, Lamy F, Tellier AC, Fantin G, Lagarrigue F, Laffon M and Fusciardi J, "The course of StO2 (NIRS) and dynamic tests with patients septische shock treated with activated drotrecogin alfa," The 36th Congress of the Societe de Reanimation de Langue Francaise; January 18, 2008; Paris, France Guyette FX, Hostler D, Suffoletto B, Cole JS, Pinsky M and Puyana JC, "Feasibility of using non-invasive measurements of circulatory shock in critical care transport," Advanced Technology Applications for Combat Casualty Care (ATACCC); August 11-13, 2008; St. Pete's Beach, FL. L'Her E, Goetghebeur D, Tonnelier J, Gut-Gobert C, Boumediene A, Renault and Boles J, "Effects of recombinant human activated protein C on endothelial function during sepsis," Intensive Care Medicine, 2005;31(Supp 1):S43. Abstract 153. Carollo T, Creteur J, De Backer D and Vincent JL, "Microvascular response to reactive hyperemia is altered in septic patients," Intensive Care Medicine, 2004;30(Supp 1):S24. Abstract 074. Carollo T, Creteur J, De Backer D and Vincent JL, "Persistent altered microvascular reactivity is predictive of mortality in septic patients," Intensive Care Medicine, 2004;30(Supp 1):S163. Abstract 626. 1.3 Diabetology
Vlassara H, Tschöpe D and Satellite A, "Food Advanced Glycation Endproducts (AGE) Acutely Induce Postprandial Impairment of Microvascular Function in Patients with Type 2 Diabetes Mellitus (T2DM), an Effect Prevented by Benfotiamine," Symposium of the 1st International Congress on Prediabetes and the Metabolic Syndrome. Dresden, Germany, April 16–18, 2005. J. Hendry, "Device Measures Tissue Oxygenation at Wound Site; May Predict Difficult-to-Heal Diabetic Foot Ulcers," Potiatry-Online 2005 D. Douglas, "Oxygen Analysis System Tracks Diabetic Foot Ulcers," Lifescan Diabetes News 2004 Alin Stirban, Burak Salgin, Theodor Koschinsky and Dan Ziegler, "Differential Role of Type 2 Diabetes and Cardiovascular Autonomic Neuropathy in Impaired Control of Skin Microcirculation (Abstract)," Presentation at the Congress of American Diabetes Association, New Orleans, 2003 1.4 Rheumatology
M. Bumann, T. Henke, H. Gerngross, L. Claes, and P. Augat, "Influence of haemorrhagic shock on fracture healing," Langenbeck's Archives of Surgery / Deutsche Gesellschaft Für Chirurgie, vol. 388, Oct. 2003, pp. 331-338. 1.5 Neurology
M. Kohl-Bareis, R. Guertler, U. Lindauer, C. Leithner, H. Sellien, G. Royl, and U. Dirnagl, "System for the Measurement of Blood Flow and Oxygenation in Tissue Applied to Neurovascular Coupling in Brain," Photon Migration and Diffuse-Light Imaging II, K. Licha and R. Cubeddu, eds., Vol. 5859 of Proc. SPIE (Optical Society of America, 2005), paper WA3. G. Royl, M. Füchtemeier, C. Leithner, D. Megow, N. Offenhauser, J. Steinbrink, M. Kohl-Bareis, U. Dirnagl, and U. Lindauer, "Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen," NeuroImage, vol. 40, May. 2008, pp. 1523-1532. C. Leithner, G. Royl, N. Offenhauser, M. Füchtemeier, M. Kohl-Bareis, A. Villringer, U. Dirnagl, and U. Lindauer, "Pharmacological uncoupling of activation induced increases in CBF and CMRO2," Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, vol. 30, Feb. 2010, pp. 311-322. Walter, B. et al., 2002. "Simultaneous measurement of local cortical blood flow and tissue oxygen saturation by Near infra-red Laser Doppler flowmetry and remission spectroscopy in the pig brain". Acta Neurochirurgica. Supplement, 81, 197-199. Selbach, M.J. et al., 1999. "Effects of elevated intraocular pressure on haemoglobin oxygenation in the rabbit optic nerve head: a microendoscopical study". Experimental Eye Research, 69(3), 301-309. 1.6 Oncology
Plasswilm, L. et al., 2000. "Hypoxia-induced tumour cell migration in an in vivo chicken model". Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology, 68(3), 99-105. S. Ibrahim, E.A. Laude, D. Bee, S. Eaton, J.D. Ward, and N.D. Harris, "Combined microlightguide spectrophotometry and microendoscopy for measurement of oxygen saturation in peripheral nerves," Physiological Measurement, vol. 20, Feb. 1999, pp. 65-73. Plasswilm, L. & Höper, J., 1997. "In vivo investigations of vascular density and local mitochondrial metabolism after irradiation". Advances in Experimental Medicine and Biology, 428, 115-122. E. De Troy, C. De Deyne, K. Vanderspeeten, F. Jans and R. Heylen, "Monitoring of Absolute Cerebral Oxygen Saturation during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Procedures," Euroanaesthesia 2009. 1.7 Pharmacology
Simon P, Mesquida J, Suffoletto B, Gomez H, Kellum J and Pinsky M, "Effect of pharmacologic vasodilation on skeletal muscle oxygen extraction," Critical Care Medicine, 2009;37(12, Suppl):A88. 1.8 Vascular and Transplant Surgery
1.8.1 Thoracic Surgery
K. Knobloch, A. Lichtenberg, M. Pichlmaier, H. Mertsching, A. Krug, U. Klima, and A. Haverich, "Microcirculation of the sternum following harvesting of the left internal mammary artery," The Thoracic and Cardiovascular Surgeon, vol. 51, Oct. 2003, pp. 255-259. Hiroyuki Kamiya, Payam Akhyari, Andreas Martens, Matthias Karck, Axel Haverich, and Artur Lichtenberg, "Sternal microcirculation after skeletonized versus pedicled harvesting of the internal thoracic artery: A randomized study," The Journal of thoracic and cardiovascular surgery, vol. 135, Jan. 2008, pp. 32-37. K. Knobloch, A. Lichtenberg, M. Pichlmaier, S. Tomaszek, A. Krug, and A. Haverich, "Palmar Microcirculation After Harvesting of the Radial Artery in Coronary Revascularization," Ann Thorac Surg, vol. 79, 2005, pp. 1026-1030. T.M. Hemmerling, R. Kazan, and D. Bracco, "Inter-hemispheric cerebral oxygen saturation differences during thoracic surgery in lateral head positioning," British Journal of Anaesthesia, vol. 102, Jan. 2009, pp. 141-142. T.M. Hemmerling, M.C. Bluteau, R. Kazan, and D. Bracco, "Significant decrease of cerebral oxygen saturation during single-lung ventilation measured using absolute oximetry," British Journal of Anaesthesia, vol. 101, Dec. 2008, pp. 870-875. T. Hemmerling, M. Bluteau, R. Kazan, and D. Bracco, "Cerebral desaturation during single lung ventilation correlates with postoperative morbidity," Canadian Journal of Anesthesia / Journal canadien d'anesthésie, vol. 55, Jun. 2008, p. 4743731. Thomas M. Hemmerling, Roy Kazan, Carmelo Minardi, Samer Charabati. and David Bracco, "Cerebral Desaturations in Thoracic Surgery: Possible Positive Correlation with Cognitive Dysfunction," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A1415 October 21, 2009 J M Fertmann. H Arbogast, E Sajzewa, A Tarabichi, W D Liner, W Land and J N Hoffmann,"Measurement of regional perfusion and oxygen saturation during human simultaneous pancreas-kidney transplantation - correlation with intravital microscopy," Proceedings of European Transplant Coordinators Organisation Congress 2003. 1.8.2 Flap Transplant
F. Hölzle, S. Swaid, D. Nolte, and K. Wolff, "Nutritive perfusion at donor site after microvascular fibula transfer," Microsurgery, vol. 23, 2003, pp. 306-312. K. Wolf, E. Höcherl, T. Derfuß and A. Krug, "Laser-doppler-flowmetry and absorption-tissue-spectrometry of the transposed groin flap - A comprehensive and independent analysis of microcirculation," Applied Cardiopulmonary Pathophysiology ll: 000-000, 2003 Hölzle F, Löffelbein D and, Swaid S, "Non-invasive tissue oxygen monitoring in fasciocutaneous flaps," Journal of Cranio-Maxillofacial Surgery (2002) 30, Supplement 1:108 1.8.3 Cardiac Surgery
G. Amir, C. Ramamoorthy, R.K. Riemer, C.R. Davis, F.L. Hanley, and V.M. Reddy, "Visual light spectroscopy reflects flow-related changes in brain oxygenation during regional low-flow perfusion and deep hypothermic circulatory arrest," The Journal of Thoracic and Cardiovascular Surgery, vol. 132, Dec. 2006, pp. 1307-1313. G.W. Fischer and M.E. Stone, "Cerebral air embolism recognized by cerebral oximetry," Seminars in Cardiothoracic and Vascular Anesthesia, vol. 13, Mar. 2009, pp. 56-59. G.W. Fischer, "Recent Advances in Application of Cerebral Oximetry in Adult Cardiovascular Surgery," Seminars in Cardiothoracic and Vascular Anesthesia, vol. 12, 2008, pp. 60-69. A.J.C. Mittnacht, G.W. Fischer, and D.L. Reich, "Methylene blue administration is associated with decreased cerebral oximetry values," Anesthesia and Analgesia, vol. 105, Aug. 2007, pp. 549-550. D.A. Benaron, I.H. Parachikov, S. Friedland, R. Soetikno, J. Brock-Utne, P.J.A. van der Starre, C. Nezhat, M.K. Terris, P.G. Maxim, J.J.L. Carson, M.K. Razavi, H.B. Gladstone, E.F. Fincher, C.P. Hsu, F.L. Clark, W. Cheong, J.L. Duckworth, and D.K. Stevenson, "Continuous, noninvasive, and localized microvascular tissue oximetry using visible light spectroscopy," Anesthesiology, vol. 100, Jun. 2004, pp. 1469-1475. Brijen L. Joshi, Kenneth Brady and Charles W. Hogue, "Real Time Monitoring of Cerebral Blood Flow Autoregulation with NIRS during Cardiac Surgery," Proceedings of the 2009 Annual Meeting of the American Society Anesthesiologists, A1102 October 20, 2009 Gregory W. Fischer, Konstandinos A. Plestis, Randall B. Griepp and David L. Reich, "Modeling the Rate of Decrease in Brain Oxygen Saturation during DHCA with Cerebral Oximetry," Anesthesiology 2008; 109 A900 Gregory W. Fischer and David L. Reich, "FORE-SIGHT Cerebral Oximeter: A Possible Solution to Methylene Blue Interference," Anesthesiology 2008; 109 A251 David MacLeod, Keita Ikeda, William White, John Keifer and Eugene Moretti, "Monitoring FORE-SIGHT Cerebral Oximeter in Cardiac Cases," Anesthesia & Analgesia 2006, 102(2S):S162 D. Macleod, K. Ikeda, W. White, J. Keifer and E. Moretti, "Pilot Study of FORE-SIGHT in Cardiac Patients," Abstracts of posters presented at the 81st clinical and scientific congress of the international anesthesia research society, 104;S-1-S-271, Orlando, Florida, March 23-27, 2007 Gregory W. Fischer, Hung-Mo Lin, Gabriele DiLuozzo, Randall B. Griepp and David L. Reich, "Risk of Post-Op Complications below Different Cerebral Oxygenation Thresholds during Aortic Surgery," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A897, October 19, 2009 Thomas M. Hemmerling, Roy Kazan, Carmelo Minardi, Samer Charabati and David Bracco, "Cerebral Desaturations in Thoracic Surgery: Possible Positive Correlation with Cognitive Dysfunction," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A1415 October 21, 2009 MacLeod D, White W, Ikeda K, Newman M and Mathew, "Decreased Forebrain Cerebral Tissue Oxygen Saturation is Associated with Cognitive Decline After Cardiac Surgery," Anesthesia & Analgesia 2009; 108(SCA Suppl);1-104, SCA8 Johsi B, Brady K, Stearns J and Hogue C, "Continuous Monitoring of Cerebral Blood Flow Autoregulation during Cardiac Surgery in Adults with NIRS," Anesthesia & Analgesia 2009; 108(SCA Suppl);1-104, SCA9 Fischer G, Lin H, DiLuozzo G, Griepp R and Reich D, "Decreased Cerebral Tissue Oxygen Saturation during Aortic Surgery Increases Risk of Post- Operative Complications," Anesthesia & Analgesia 2009; 108(SCA Suppl);1-104 Pieter Van der Starre, Anant Chandel, David Benaron and John Brock-Utne, "First Clinical Experiences with Non-Pulsatile Optical Diffusion Tissue Oximetry during Cardiopulmonary Bypass," Anesthesiology 2003; 99: A558. 1.8.4 Carotid Surgery
Kevin M. Lathouwers, Cathy S. De Deyne, Roel Mestrum, Geert Lauwers and René, J. Heylen, "Non-Invasive Absolute Cerebral Oximetry (FORE-SIGHT) during Shunting Procedure for Carotid Surgery," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A748 October 19, 2009 Kevin M. Lathouwers, Cathy S. De Deyne, Wouter Lansink, Roel Mestrum And René J. Heylen, "Non-Invasive Absolute Cerebral Oximetry (FORE-SIGHT) during Carotid Endarterectomy," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A1114 October 20, 2009 J. Sterken, C. De Deyne, W. Lansink, G. Lauwers, K. Lathouwers, M. Vander Laenen, F. Jans and R. Heylen, "Monitoring SctO2 (FORE-SIGHT) to Detect Cerebral Hyperperfusion after Carotid Endarterectomy," Abstract A-193-0046-01706 of the Annual Congress of European Society of Intensive Care Medicine, 2009. Stoffel Lamote, Cathy De Deyne, Wouter Lansink, Frank Jans and Rene Heylen, "Non-invasive monitoring of absolute cerebral oxygen saturation (FORE-SIGHT, CASMED) during elective shunting procedure for carotid endarterectomy," Euroanaesthesia 2009 1.8.5 Orthopaedic Surgery
Glenn S. Murphy, Joseph W. Szokol, Jessica A. Vaughn, Jesse H. Marymont and Jeffery S. Vender, "The Incidence of Cerebral Oxygen Desaturation Events during Surgery in the Beach Chair Position," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A620 October 18, 2009 Kevin M. Lathouwers, Cathy S. De Deyne, Frank Jans, Jan Truijen. and René J. Heylen, "Absolute Cerebral Oximetry (FORE-SIGHT) in the Benchchair Position for Shoulder Surgery," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A1288 October 20, 2009 Roy Somers, Cathy De Deyne, Frank Jans, Jan Oosterbosch and Rene Heylen, "Monitoring of absolute cerebral oxygen saturation (FORE-SIGHT Technology) during endoscopic shoulder surgery: benchchair positioing compared to conventional positioning," Euroanaesthesia 2009 G.W. Fischer, T.M. Torrillo, M.M. Weiner, and M.A. Rosenblatt, "The use of cerebral oximetry as a monitor of the adequacy of cerebral perfusion in a patient undergoing shoulder surgery in the beach chair position," Pain Practice: The Official Journal of World Institute of Pain, vol. 9, Aug. 2009, pp. 304-307. S. Vanden Boer, C. De Deyne, F. Weyns, T. Daenekindt, F. Jans, M. Vander Laenen and R. Heylen, "Monitoring SctO2 (FORE-SIGHT) during Craniotomy for Acute Intracerebral Bleeding," Annual Congress of European Society of Intensive Care Medicine 2009 K. D'Haeseleer, C. De Deyne, J. Wuyts, D. Peuskens, M. Vander Laenen, F. Jans and R. Heylen, "Non-Invasive Monitoring of Cerebral Brain Oxygen Saturation for Complex Cerebral Aneurysm Surgery," Annual Congress of European Society of Intensive Care Medicine 2009 I. Bertrand, C. De Deyne, J. Wuyts, F. Jans and R. Heylen, "Monitoring of Absolute Cerebral Oxygen Saturation during Complex Cerebral Aneurysm Surgery by Absolute cerebral oxygen saturation (FORE-SIGHT Technology)," Euroanaesthesia 2009 John Brock-Utne, Eugene S. Lee Arie Bass, Frank R. Arko, E. John Harris Jr, Christopher K. Zarins, Pieter van der Starre, Mahmood K. Razavi and Cornelius Cornelius Olcott IV, "Intraoperative Colon Mucosal Oxygen Saturation Can Predict and Possibly Prevent Colon Ischemia During Aortic Aneurysm Repair," Presentation at ASA 2005 S Friedland, R Soetikno, V Gowra and G Singh, "Detection of Enteric Ischemia Using T-Stat," Presentation at Digestive Disease Week 2005, May 14 - 19, 2005; Chicago, Illinois E.S. Lee, A. Bass, F.R. Arko, M. Heikkinen, E.J. Harris, C.K. Zarins, P. van der Starre, and C. Olcott, "Intraoperative Colon Mucosal Oxygen Saturation During Aortic Surgery," Journal of Surgical Research, vol. 136, Nov. 2006, pp. 19-24. SL Wang, DY Sze, MD Dake, S Friedland, DA Benaron, and MK Razavi, "Continuous gastrointestinal mucosal oximetry during endovascular procedures carrying risk of ischemia," Presented at: 2004 SIR Annual Scientific Meeting Conference Phoenix AZ March 30 – April 1, 2004 1.9 Intensive Care
1.9.1 Neonatal Intensive Care
A tissue oxygen saturation monitor provides a new approach to measure neonatal haemoglobin levels. Comparing with the traditional way of venipuncture, it is non-invasive, hence reducing pain, iatrogenic blood loss and the risk of neonatal anaemia. Rabe, H. et al., 2005. "Measurement of transcutaneous hemoglobin concentration by noninvasive white-light spectroscopy in infants". Pediatrics, 116(4), 841-843. Rabe, H. et al., 2010. "Spectroscopic noninvasive measurement of hemoglobin compared with capillary and venous values in neonates". Neonatology, 98(1), 1-5. P. Benni, B. Chen, F. Dykes, S. Wagoner, M. Heard, A. Tanner, T. Young, K. Rais-Bahrami, O. Rivera, and B. Short, "Validation of the Cas Neonatal NIRS System by Monitoring VV-ECMO Patients," Oxygen Transport to Tissue XXVI, N. Back, I.R. Cohen, A. Lajtha, J.D. Lambris, R. Paoletti, P. Okunieff, J. Williams, and Y. Chen, Eds., Springer US, 2005, pp. 195-201. K. Rais-Bahrami, "Neonatal cerebral oximetry monitoring during ECMO cannulation," Journal of Perinatology, vol. 29, 2009, pp. 376-381. K. Rais-Bahrami, O. Rivera, and B.L. Short, "Validation of a noninvasive neonatal optical cerebral oximeter in veno-venous ECMO patients with a cephalad catheter," Journal of Perinatology: Official Journal of the California Perinatal Association, vol. 26, Oct. 2006, pp. 628-635. D.A. Benaron, I.H. Parachikov, S. Friedland, R. Soetikno, J. Brock-Utne, P.J.A. van der Starre, C. Nezhat, M.K. Terris, P.G. Maxim, J.J.L. Carson, M.K. Razavi, H.B. Gladstone, E.F. Fincher, C.P. Hsu, F.L. Clark, W. Cheong, J.L. Duckworth, and D.K. Stevenson, "Continuous, noninvasive, and localized microvascular tissue oximetry using visible light spectroscopy," Anesthesiology, vol. 100, Jun. 2004, pp. 1469-1475 David B. MacLeod, Richard J. Ing, Keita Ikeda, Warwick A. Ames and Scott R. Schulman, "Measurement of Absolute Viscerosomatic Tissue Oxygen Saturation: Preliminary Results," Proceedings of the Annual Meeting of the American Society Anesthesiologists, A931 October 19, 2009 Barry D. Kussman, Peter C. Laussen, Paul B. Benni, Doff B. McElhinney and Francis X. McGowan, Jr., "Validation of the FORE-SIGHT Pediatric NIRS Cerebral Oximeter," Anesthesiology, Perioperative & Pain Medicine, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, A685 October 19, 2009 Chandra Ramamoorthy, Gabriel Amir, Robert K. Riemer, Akio Ikai and Vadiyala M. Reddy, "Prospective Detection of Tissue Ischemia during Hypothermic Circulatory Arrest Using Visible Light Spectroscopy," Anesthesiology 2004; 101: A1513, October 23-27, 2004, Las Vegas, Nevada. 1.9.2 Haemorrhage
Since haemorrhage may lead to ischaemia, a fundamental goal of initial therapy is to ensure adequate organ perfusion and delivery of oxygen as fast as possible to prevent irreversible damage. Tissue oxygen saturation monitors have been demonstrated to detect peripheral tissue hypo-perfusion. L. Heyer, A. Mebazaa, E. Gayat, M. Resche-Rigon, C. Rabuel, E. Rezlan, A. Lukascewicz, C. Madadaki, R. Pirracchio, P. Schurando, O. Morel, Y. Fargeaudou, and D. Payen, "Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S8. S.G. Sagraves, M.A. Newell, M.R. Bard, F.R. Watkins, K.J. Corcoran, P.D. McMullen, and M.F. Rotondo, "Tissue oxygenation monitoring in the field: a new EMS vital sign," The Journal of Trauma, vol. 67, Sep. 2009, pp. 441-443; discussion 443-444. Santora, R.J. & Moore, F.A., 2009. Monitoring trauma and intensive care unit resuscitation with tissue hemoglobin oxygen saturation. Critical Care (London, England), 13 Suppl 5, S10. G.J. Beilman and J.J. Blondet, "Near-infrared spectroscopy-derived tissue oxygen saturation in battlefield injuries: a case series report," World Journal of Emergency Surgery: WJES, vol. 4, 2009, p. 25. L.N. Kiraly, S. Underwood, J.A. Differding, and M.A. Schreiber, "Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients," The Journal of Trauma, vol. 67, Jul. 2009, pp. 29-32. M.E. George, G.J. Beilman, K.E. Mulier, D.E. Myers, and K.R. Wasiluk, "Noninvasive tissue oxygen saturation measurements identify supply dependency," The Journal of Surgical Research, vol. 160, May. 2010, pp. 40-46. G.J. Beilman, J.J. Blondet, T.R. Nelson, A.B. Nathens, F.A. Moore, P. Rhee, J.C. Puyana, E.E. Moore, and S.M. Cohn, "Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality," Annals of Surgery, vol. 249, May. 2009, pp. 845-850. A.C. Beekley, M.J. Martin, T. Nelson, K.W. Grathwohl, M. Griffith, G. Beilman, and J.B. Holcomb, "Continuous noninvasive tissue oximetry in the early evaluation of the combat casualty: a prospective study," The Journal of Trauma, vol. 69 Suppl 1, Jul. 2010, pp. S14-25. J. Crawford, R. Otero, E. Rivers, and D. Goldsmith, "Near-infrared spectroscopy as a potential surrogate for mixed venous oxygen saturation for evaluation of patients with hemodynamic derangements," Critical Care, vol. 12, 2008, p. P69. M.S. Englehart, C.E. Allison, B.H. Tieu, L.N. Kiraly, S.A. Underwood, P.J. Muller, J.A. Differding, R.S. Sawai, A. Karahan, and M.A. Schreiber, "Ketamine-based total intravenous anesthesia versus isoflurane anesthesia in a swine model of hemorrhagic shock," The Journal of Trauma, vol. 65, Oct. 2008, pp. 901-908; discussion 908-909. L.N. Kiraly, S. Underwood, J.A. Differding, and M.A. Schreiber, "Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients," The Journal of Trauma, vol. 67, Jul. 2009, pp. 29-32. J.R. Miner, G. Petersen, C. Byrd, J. Clinton, and S. Smith, "The Relationship Between Near Infrared Spectroscopy and End Tidal Carbon Dioxide in Patients Presenting With Shock," Annals of emergency medicine, vol. 52, Oct. 2008, pp. S57-S58. F.A. Moore, T. Nelson, B.A. McKinley, E.E. Moore, A.B. Nathens, P. Rhee, J.C. Puyana, G.J. Beilman, and S.M. Cohn, "Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?," American Journal of Surgery, vol. 196, Dec. 2008, pp. 948-958; discussion 958-960. F.A. Moore, T. Nelson, B.A. McKinley, E.E. Moore, A.B. Nathens, P. Rhee, J.C. Puyana, G.J. Beilman, and S.M. Cohn, "Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome," The Journal of Trauma, vol. 64, Apr. 2008, pp. 1010-1023. Skarda, D.E. et al., 2008. Eight hours of hypotensive versus normotensive resuscitation in a porcine model of controlled hemorrhagic shock. Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine, 15(9), 845-852. J. Smith, S. Bricker, and B. Putnam, "Tissue oxygen saturation predicts the need for early blood transfusion in trauma patients," The American Surgeon, vol. 74, Oct. 2008, pp. 1006-1011. G.J. Beilman, J.J. Blondet, T.R. Nelson, A.B. Nathens, F.A. Moore, P. Rhee, J.C. Puyana, E.E. Moore, and S.M. Cohn, "Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality," Annals of Surgery, vol. 249, May. 2009, pp. 845-850. S.M. Cohn, A.B. Nathens, F.A. Moore, P. Rhee, J.C. Puyana, E.E. Moore, and G.J. Beilman, "Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation," The Journal of Trauma, vol. 62, Jan. 2007, pp. 44-54; discussion 54-55. S. Zenker, P.M. Polanco, H.K. Kim, A. Torres, Y. Vodovotz, G. Clermont, M.R. Pinsky, D.A. Severyn, and J.C. Puyana, "Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock," The Journal of Trauma, vol. 63, Sep. 2007, pp. 573-578; discussion 578-580. G.J. Beilman, A.B. Nathens, F.A. Moore, P. Rhee, J. Puyana, E.E. Moore, and S.M. Cohn, "Non-Invasive Near Infrared Spectroscopy-Derived StO2 Predicts Mortality in Severe Traumatic Injury," Annals of emergency medicine, vol. 48, Oct. 2006, p. 2. M. Englehart, B. Tieu, L. Kiraly, R. Sawai, and M. Schreiber, "The Influence of Anesthesia on A Swine Model of Hemorrhagic Shock," Shock, vol. 25, 2006. J.M. Watters, B.H. Tieu, J.A. Differding, P.J. Muller, and M.A. Schreiber, "A single bolus of 3% hypertonic saline with 6% dextran provides optimal initial resuscitation after uncontrolled hemorrhagic shock," The Journal of Trauma, vol. 61, Jul. 2006, pp. 75-81. B.A. Crookes, S.M. Cohn, S. Bloch, J. Amortegui, R. Manning, P. Li, M.S. Proctor, A. Hallal, L.H. Blackbourne, R. Benjamin, D. Soffer, F. Habib, C.I. Schulman, R. Duncan, and K.G. Proctor, "Can near-infrared spectroscopy identify the severity of shock in trauma patients?," The Journal of Trauma, vol. 58, Apr. 2005, pp. 806-813; discussion 813-816. J.H. Taylor, K.E. Mulier, D.E. Myers, and G.J. Beilman, "Use of near-infrared spectroscopy in early determination of irreversible hemorrhagic shock," The Journal of Trauma, vol. 58, Jun. 2005, pp. 1119-1125. B.A. Crookes, S.M. Cohn, E.A. Burton, J. Nelson, and K.G. Proctor, "Noninvasive muscle oxygenation to guide fluid resuscitation after traumatic shock," Surgery, vol. 135, Jun. 2004, pp. 662-670. Taylor, J.H. et al., 2004. Tissue energetics as measured by nuclear magnetic resonance spectroscopy during hemorrhagic shock. Shock (Augusta, Ga.), 21(1), 58-64. S.M. Cohn, B.A. Crookes, and K.G. Proctor, "Near-infrared spectroscopy in resuscitation," The Journal of Trauma, vol. 54, May. 2003, pp. S199-202. S.M. Cohn, J.E. Varela, G. Giannotti, M.O. Dolich, M. Brown, A. Feinstein, M.G. McKenney, and P. Spalding, "Splanchnic perfusion evaluation during hemorrhage and resuscitation with gastric near-infrared spectroscopy," The Journal of Trauma, vol. 50, Apr. 2001, pp. 629-634; discussion 634-635. B.A. McKinley, R.G. Marvin, C.S. Cocanour, and F.A. Moore, "Tissue hemoglobin O2 saturation during resuscitation of traumatic shock monitored using near infrared spectrometry," The Journal of Trauma, vol. 48, Apr. 2000, pp. 637-642. G.J. Beilman, K.E. Groehler, V. Lazaron, and J.P. Ortner, "Near-infrared spectroscopy measurement of regional tissue oxyhemoglobin saturation during hemorrhagic shock," Shock (Augusta, Ga.), vol. 12, Sep. 1999, pp. 196-200. P. Rhee, L. Langdale, C. Mock, and L.M. Gentilello, "Near-infrared spectroscopy: continuous measurement of cytochrome oxidation during hemorrhagic shock," Critical Care Medicine, vol. 25, Jan. 1997, pp. 166-170. Guyette F, Gomez H, Suffoletto B, Quintero J, Mesquida J, Kim HK, Hostler D, Puyana J and Pinsky M, "Prehospital dynamic tissue O2 saturation response predicts in-hospital mortality in trauma patients," Critical Care Medicine, 2009;37(12, Suppl):A28. Crawford J, Otero R, Rivers E, Goldsmith D and Ristova S, "Near infrared spectroscopy to assess systemic perfusion in the critically ill," SCCM Critical Care Congress; February 2-6, 2008; Honolulu, HI. Guyette FX, Hostler D, Suffoletto B, Cole JS, Pinsky M and Puyana JC, "Feasibility of using non-invasive measurements of circulatory shock in critical care transport," Advanced Technology Applications for Combat Casualty Care (ATACCC); August 11-13, 2008; St. Pete's Beach, FL. Hinkelbein J, Rokuss K, Kalenka A and Bender H, "Near-infrared spectroscopy to monitor tissue oxygenation in critically ill patients," European Journal of Anaesthesiology, 2008;25(Suppl S44):3AP5-9. Neves A, Ventura A, Boreli V, Zattar F, Creteur J and Vincent J, "Does red blood cell transfusion improve tissue oxygenation in critically ill patients?," Intensive Care Medicine, 2008;34(Supp 1):S257. Abstract 1010. Otero R, Crawford J, Goldsmith D and Ristova S, "A comparison of near infra-red spectroscopy with endpoints of resuscitation for evaluation of critically ill patients," ISICEM; March 18-21, 2008; Brussels, Belgium. Pottecher J, Mathe O, Laplace C, Mesnil M, Repesse X, Benhamou D and Duranteau, "Microvascular dysfunction in trauma hemorrhagic shock : Assessment with near infrare specetroscopy during occlusion tests," Journal of Intensive Care Medicine, 2008;34(1):S257. Abstract 1007. Haas B, Rosengart MR, Nelson T and Nathens AB, "Attributable costs and LOS of post-traumatic multiple organ failure," AAST 66th Annual Meeting; September 27-29, 2007; Las Vegas, NV. Moore F, McKinley B, Moore E, Nathens A, Rhee P, Puyana J, Beilman G, Cohn S, "Need for massive transfusion can be predicted early after trauma center arrival" Journal of Trauma, 2007;62(1):270 Puyana JC, Polanco PM, Peitzman AB, Nathens AB, Moore FA, Rhee P, Beilman GJ, Moore EE and Cohn SM, "Noninvasive near infrared spectroscopy-(NIRS) StO2 predicts early death in patients with severe hemorrhage and massive transfusion" SCCM Critical Care Congress; Feb 17-21, 2007; Orlando, FL Robertson S, Dickson E abd Richards G, "Peripheral oxygen extraction predicts organ failure and mortality following major trauma," Critical Care, 2007;11(Supp 2):S141. Abstract P351 Rokuss K, Hinkelbein J, Kalenka A and Bender HJ, "Near-infrared spectroscopy to monitor tissue oxygenation in critically ill patients," Proceedings of the 9th Capital City Conference of the DGAI Congress of Anesthesiology and Intensive Care Medicine; September 13-15, 2007; Berlin, Germany. Heyer L, Rezlan E, Madadaki K, Rabuel C, Schourando P and Payen D, "Diffuse micro-oxygenation impairment in acute haemorragic shock," Intensive Care Medicine, 2006;32(Supp 1):S168. Abstract 0643 Mesquida J, Maluenda M, Masip J, Baigorri F and Artigas A, "Oxygen tissular saturation (StO2) measured by NIRS in patients admitted to the intensive care unit," Intensive Care Medicine, 2006;32(Supplement 1):S167. Abstract 0640. Otero R, Crawford J, Rivers EP, Nwoke P and Sankey SS, "Near infrared spectroscopy as an indicator of systemic perfusion in acutely ill patients in the emergency department," American College of Emergency Physicians (ACEP) Research Forum; October 15-16, 2006; New Orleans, LA. Puyana JC, Polanco PM, Peitzman AB, Nathens AB, Moore FA, Rhee P, Beilman GJ, Moore EE and Cohn SM, "Tissue O2 saturation is an early indicator of mortality and blood transfusion needs in severe trauma," Intensive Care Medicine, 2006;32(Supp 1):S8. Abstract 0014. Torres PA, Polanco P, Pinsky M, Kim and Puyana JC, "Non-invasive real-time quantification of cardiovascular reserve in human circulatory shock". Journal of Surgical Research, 2006;130(2):279. Abstract 323. Torres PA, Polanco P, Pinsky M, Kim and Puyana JC, "Non-invasive real-time quantification of cardiovascular reserve in human circulatory shock". Proceedings of the First Annual Academic Surgical Congress; February 7-11, 2006; San Diego, CA. Torres PA, Polanco PM, Rosengart MR, Peitzman AB, Harbrecht BG, Forsythe RM and Kim HK, "Real time – bedside non invasive measurement of tissue hemoglobin as a surrogate of blood hemoglobin during shock and resuscitation," Proceedings of the 19th Annual Scientific Meeting of the Eastern Association for the Surgery of Trauma; January 10-14, 2006; Orlando, FL. Heyer L, Rezlan E, Madadaki C and Payen D, "Comparison of tissue hemoglobin oxygen saturation in post-partum hemorrhagic shock patients and septic patients," Society of Critical Care Medicine 31st Critical Care Congress; January 26-30, 2002; San Diego, CA. 1.9.3 Sepsis
Microvascular dysfunction has been shown to play a significant role in the pathogenesis of sepsis and is a potential new target in the management of sepsis. Real-time assessment of microcirculation using tissue oxygen saturation monitor provides key insights into prognosis in sepsis and guide future therapeutics. A. Lima, J. van Bommel, T.C. Jansen, C. Ince, and J. Bakker, "Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S13. A. Donati, M. Romanelli, L. Botticelli, A. Valentini, V. Gabbanelli, S. Nataloni, T. Principi, P. Pelaia, R. Bezemer, and C. Ince, "Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy," Critical Care (London, England), vol. 13 Suppl 5, 2009, p. S12. J. Creteur, A.P. Neves, and J. 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Schmidt, and W.G. Haynes, "Impairments in microvascular reactivity are related to organ failure in human sepsis," American Journal of Physiology. Heart and Circulatory Physiology, vol. 293, Aug. 2007, pp. H1065-1071. D.E. Skarda, K.E. Mulier, D.E. Myers, J.H. Taylor, and G.J. Beilman, "Dynamic near-infrared spectroscopy measurements in patients with severe sepsis," Shock (Augusta, Ga.), vol. 27, Apr. 2007, pp. 348-353. D.E. Skarda, K.E. Mulier, D.E. Myers, J.H. Taylor, and G.J. Beilman, "Dynamic near-infrared spectroscopy measurements in patients with severe sepsis," Shock (Augusta, Ga.), vol. 27, Apr. 2007, pp. 348-353. X. Borrat, G. Sanchez-Etayo, R. Adalia, M.J. Arguis, F.J. Tercero, M. Barroso, S. Benito, and E. Zavala, "Non-invasive tissue oxygen monitoring in septic shock patients: an observational study: A-764," European Journal of Anaesthesiology, vol. 23, 2006. R. Pareznik, R. Knezevic, G. Voga, and M. Podbregar, "Changes in muscle tissue oxygenation during stagnant ischemia in septic patients," Intensive Care Medicine, vol. 32, Jan. 2006, pp. 87-92. D. Skarda, J. Taylor, K. Mulier, D. Myers, and G. Beilman, "Dynamic near-infrared spectroscopy measurements in patients with severe sepsis correlate with invasive hemodynamic measurements," Critical Care, vol. 9, 2005, p. P74. J. Crawford, R. Otero, E. Rivers, and D. Goldsmith, "Near-infrared spectroscopy as a potential surrogate for mixed venous oxygen saturation for evaluation of patients with hemodynamic derangements," Critical Care, vol. 12, 2008, p. P69. J.R. Miner, G. Petersen, C. Byrd, J. Clinton, and S. Smith, "The Relationship Between Near Infrared Spectroscopy and End Tidal Carbon Dioxide in Patients Presenting With Shock," Annals of emergency medicine, vol. 52, Oct. 2008, pp. S57-S58. Nardi, O. et al., 2010. Masseter muscle oxygen saturation is associated with central venous oxygen saturation in patients with severe sepsis. Journal of Clinical Monitoring and Computing, 24(4), 289-293. Mozina, H. & Podbregar, M., 2010. Near-infrared spectroscopy during stagnant ischemia estimates central venous oxygen saturation and mixed venous oxygen saturation discrepancy in patients with severe left heart failure and additional sepsis/septic shock. Critical Care (London, England), 14(2), R42. Napoli, A.M. et al., 2010. Tissue oxygenation does not predict central venous oxygenation in emergency department patients with severe sepsis and septic shock. Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine, 17(4), 349-352. C. Vorwerk, "Normalisation of tissue oxygen saturation in ED patients with severe sepsis or septic shock is related to mortality," Emergency Medicine Journal, vol. 26:, Oct. 2009, p. 6. M. Leone, S. Blidi, F. Antonini, B. Meyssignac, S. Bordon, F. Garcin, A. Charvet, V. Blasco, J. Albanèse, and C. Martin, "Oxygen tissue saturation is lower in nonsurvivors than in survivors after early resuscitation of septic shock," Anesthesiology, vol. 111, Aug. 2009, pp. 366-371. J. Mesquida, J. Masip, G. Gili, A. Artigas, and F. Baigorri, "Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients," Intensive Care Medicine, vol. 35, Jun. 2009, pp. 1106-1109. A. Lima, T. Jansen, C. Ince, and J. Bakker, "Noninvasive monitoring of peripheral perfusion with physical examination and the peripheral flow index correlates with dynamic near-infrared spectroscopy measurements in patients with septic shock," Critical Care, vol. 12, 2008, p. P60. Mulier, K.E. et al., 2008. Near-infrared spectroscopy in patients with severe sepsis: correlation with invasive hemodynamic measurements. Surgical Infections, 9(5), 515-519. T. Steinbuechel, S. Peiniger, B. Bouillon, F. Wappler, and S.G. Sakka, "Can transcutaneous oxygen saturation be used to detect tissue hypoperfusion?," Intensive Care Medicine, vol. 34, Aug. 2008, pp. 1546-1547. S. Klinzing, C. Reinhard, T. Simon, T. Schurholz, Y. Sakr, K. Reinhart, and G. Marx, "Vasopressin substitution causes microcirculatory changes in patients with septic shock," Critical Care, vol. 11, 2007, p. P34. Podbregar, M. & Mozina, H., 2007. Skeletal muscle oxygen saturation does not estimate mixed venous oxygen saturation in patients with severe left heart failure and additional severe sepsis or septic shock. Critical Care (London, England), 11(1), R6. Puyana, J.C. & Pinsky, M.R., 2007. Searching for non-invasive markers of tissue hypoxia. Critical Care (London, England), 11(1), 116. Pickkers, P. et al., 2006. Changes in the microcirculation during human endotoxemia measured with near-infrared spectroscopy. Critical Care, 10(Suppl 1), P320. Poeze, M., 2006. Tissue-oxygenation assessment using near-infrared spectroscopy during severe sepsis: confounding effects of tissue edema on StO2 values. Intensive Care Medicine, 32(5), 788-789. B. Atasever, A. van der Veen, P. Goedhart, B. de Mol, and C. Ince, "Sublingual NIRS and reflectance spectrophotometry: new methods to monitor sublingual oxygen availability," Critical Care, vol. 9, 2005, p. P73. Y. Kwon, S.H. Lee, H.C. Ryoo, and H. Patrick, "Non-Invasive Thenar Muscle Tissue Oxygen Saturation As A Surrogate of Central Venous Oxygen Saturation in Patients With Severe Sepsis.: 223-T," Critical Care Medicine, vol. 33, 2005. K. Frank, R. Funk, M. Kessler, and J. Rohen, "Spectrometric measurements in the anterior eye vasculature of the albino rabbit--A study with the EMPHO I," Experimental Eye Research, vol. 52, Mar. 1991, pp. 301-309. Thooft A, Favory R, Salgado DR, De Backer D, Vincent JL, Creteur J, "Effects of increasing mean arterial pressure with norepinephrine on microvascular reactivity in septic shock patients," Journal of Intensive Care Medicine, 2009;35(Suppl 1):S80 Mayeur C, Campard S, Richard C and Teboul JL, "Comparison of different vascular occlusion tests to assess microcirculatory disturbances with NIRS," Intensive Care Medicine, 2009;35(Suppl 1):S81 Favory, Ospina-Tascon G, Donadello K, Simion D, Neves AP, Occhipinti G, Oliveira T, Fonseca A, Creteur J, Vincent JL and De Backer D, "Is there a correlation between near infrared spectroscopy and side dark field imaging?," Intensive Care Medicine, 2009;35(Suppl 1):S205 Creteur J, Neves AP, Ospina G, De Backer D, Vincent JL, "Muscle oxygen consumption is related to the degree of microvascular dysfunction in patients with severe sepsis," Intensive Care Medicine, 2009;35(Suppl 1):S104 Cavazzuti I, Rinaldi L, Braccini MS, Bertolotti V, Andreotti A, Busani S, Girardis M, "Effects of intravenous IGM-enriched immunoglobulins on muscle tissue mircrocirculation in septic shock: a preliminary report," Intensive Care Medicine, 2009;35(Suppl 1):S239 Allan C, Philips H, Kemp J, Celinski M and Jonas M, "Near infrared spectroscopy (NIRS) and its comparison with traditional parameters of oxygen delivery in septic intensive care patients," Intensive Care Medicine, 2009;35(Suppl 1):S28 Napoli A, Forcada A, Corl K and Gardiner F, "Accuracy of near infrared spectroscopy in predicting central venous mixed oxygenation in the emergency department," Academic emergency medicine, 2009;16(S1):S8. Crawford J, Otero R, Rivers E, Goldsmith D and Ristova S, "Near infrared spectroscopy to assess systemic perfusion in the critically ill," SCCM Critical Care Congress; February 2-6, 2008; Honolulu, HI. Creteur J, Neves AP, Ospina G, Oliveira T, De Backer D and Vincent JL, "The prognostic value of NIRS-derived variables in patients with severe sepsis," Critical Care Medicine, 2008;36(12, Abstract Supplement):A158. Abstract 621. Creteur J and Vincent JL, "NIRS determination of tissue oxygenation in sepsis". International Journal of Intensive Care, 2008;Summer:19-22. Donati A, Romanelli M, Romagnoli L, Botticelli L, Anastasi C and Pelaia P, "Microcirculatory changes after activated protein-C infusion in severe sepsis," Intensive Care Medicine, 2008;34(Supp 1):S104. Abstract 0395. Ferrandiere M, Lamy F, Tellier AC, Fantin G, Lagarrigue F, Laffon M and Fusciardi J, "The course of StO2 (NIRS) and dynamic tests with patients septische shock treated with activated drotrecogin alfa," The 36th Congress of the Societe de Reanimation de Langue Francaise; January 18, 2008; Paris, France Georger JF, Chaari A, Richard C and Teboul JL, "Effects of activated protein C on microcirculation assessed by near infrared spectroscopy," Intensive Care Medicine, 2008;34(Supp 1):S256. Abstract 1004 Georger JF, Chaari A, Richard C and Teboul JL, "Effects of fluid resuscitation on microcirculation assessed by near infrared spectroscopy in septic patients," Intensive Care Medicine, 2008;34(Supp 1):S66. Abstract 0247. Hinkelbein J, Rokuss K, Kalenka A and Bender H, "Near-infrared spectroscopy to monitor tissue oxygenation in critically ill patients," European Journal of Anaesthesiology, 2008;25(Suppl S44):3AP5-9. Mesquida J, Martinez M, Artigas A and Baigorri F, "Thenar oxygen saturation measured by near-infrared spectroscopy: a mortality predictor in septic patients," Intensive Care Medicine, 2008;34(Supp 1):S256. Abstract 1003 Mesquida J, Masip J, Gili G, Sabatier C, Baigorri F and Artigas A, "Tissular oxygen saturation measured by near-infrared spectroscopy as a non-invasive predictor of low central venous oxygen saturation: a useful parameter in our resuscitation algorithm?" American Journal of Respiratory and Critical Care Medicine, 2008;177(Abstracts Issue):A366. Mozina H and Podbregar M, "Near infrared spectroscopy during stagnant ischemia a marker of ScvO2 - SvO2 mismatch in septic patients with low cardiac output," Critical Care, 2008;12(Suppl 2):S28-S29. Abstract P72. Neves A, Ventura A, Boreli V, Zattar F, Creteur J and Vincent J, "Does red blood cell transfusion improve tissue oxygenation in critically ill patients?," Intensive Care Medicine, 2008;34(Supp 1):S257. Abstract 1010. Otero R, Crawford J, Goldsmith D and Ristova S, "A comparison of near infra-red spectroscopy with endpoints of resuscitation for evaluation of critically ill patients," ISICEM, March 18-21, 2008; Brussels, Belgium. Creteur J, Ospina G, Oliveira Silva T, De Backer D and Vincent J, "Muscle oxygen saturation cannot predict central venous oxygen saturation in patients with severe sepsis," Intensive Care Medicine, 2007;33(Supp 2):S6. Abstract 0006. Georger JF, Chaari A, Richard C and Teboul JL, "Can near infrared spectroscopy detect functional microcirculation abnormalities in septic patients?," Intensive Care Medicine, 2007;33(Supp 2):S254. Abstract 0987. Georger JF, Chaari A, Richard C and Teboul JL, "Effects of norepinephrine on regional perfusion assessed by near infrared spectroscopy in patients with septic shock," Intensive Care Medicine, 2007;33(Supp 2):S166. Abstract 0641 Kierzek G, Didden S, Bonnetain F, Deville C and Pourriat JL, "Advantage and feasibility of using the InSpectra 325™ Tissue Spectometer in an emergency department," Anesthesiology, 2007;107:A1270. Payen D, Damoisel C, Heyer L, Luengo C, Kerever S and Losser MR, "Evaluation of thenar hemoglobin oxygen saturation (StO2) items as outcome markers at day 0 of human septic shock," Critical Care Medicine, 2007;35(12, Abstract Supplement):A271. Abstract 975. Payen D, Heyer L, Damoisel C, Kerever S, Luengo C and Losser MR, "Assessment by StO2 of peripheral tissue perfusion improvement with activated protein C (APC) in human septic shock," Critical Care Medicine, 2007;35(12, Abstract Supplement):A279. Abstract 1005. Pujol W, Vargas F, Bui HN, Clouzeau B, Herpe B, Medrano J, Garnier S, Boyer A, Pillet O, Gruson D, Hilbert G, Gbikpi-Benissan G and Castaing Y, "Skeletal muscle dynamic near-infraread spectroscopy measurements in patients with septic shock," Critical Care Medicine, 2007;35(12, Abstract Supplement):A77. Abstract 293. Rokuss K, Hinkelbein J, Kalenka A and Bender HJ, "Near-infrared spectroscopy to monitor tissue oxygenation in critically ill patients," Proceedings of the 9th Capital City Conference of the DGAI Congress of Anesthesiology and Intensive Care Medicine, September 13-15, 2007; Berlin, Germany. Simon T, Schuerholz T, Petzel P Haugvik S, Klinzing S and Marx G, "Tissue oxygen saturation: an indicator for systemic oxygenation in experimental sepsis," Intensive Care Medicine, 2007;33(Supp 2):S31. Abstract 0105 Borrat X, Sanchez-Etayo G, Mercadal J, Tercero F, De la Riba N, Israel T, Adalia R and Zabala E, "NIRS assessment of microcirculation in septic and polytraumatized patients," Intensive Care Medicine, 2006;32(Supp 1):S172. Abstract 0657. Creteur J, Buchele G, Sales Jr J, Ospina G and Vincent J, "Muscle oxygen consumption is decreased in septic patients," Intensive Care Medicine, 2006;32(Supp 1):S290. Abstract 1126. Heyer L, Madadaki C, Rezlan E, Welschbillig S, Mateo J and Payen D, "Differential micro-oxygenation dysfunction in haemorrhagic and septic shock patients," Intensive Care Medicine, 2006;32(Supp 1):S254. Abstract 0982 Klinzing S, Reinhard C, Simon T, Reinhart K and Marx G, "Microcirculatory changes in patients with sepsis or septic shock under vasopressin substitution," Intensive Care Medicine, 2006;32(Supp 1):S201. Abstract 0773. Mesquida J, Maluenda M, Masip J, Baigorri F and Artigas A, "Oxygen tissular saturation (StO2) measured by NIRS in patients admitted to the intensive care unit," Intensive Care Medicine, 2006;32(Supplement 1):S167. Abstract 0640. Mozina H, Strahovnik I and Podbregar M, "Muscle oxygenation in low flow state and sepsis: correlation to hemodynamics and outcome," Intensive Care Medicine, 2006;32(Supp 1):S290. Abstract 1128. Otero R, Crawford J, Rivers EP, Nwoke P and Sankey SS, "Near infrared spectroscopy as an indicator of systemic perfusion in acutely ill patients in the emergency department," American College of Emergency Physicians (ACEP) Research Forum; October 15-16, 2006; New Orleans, LA. Renieris P, Gerovasili V, Poriazi M, Loukas T, Markaki V, Routsi C, Roussos C and Nanas S, "Microcirculatory dysfunction in ICU patients with sepsis," Intensive Care Medicine, 2006;32(Supp 1):S98. Abstract 0371. Rinaldi L, Busani S and Girardis M, "Muscle tissue oxygenation in septic patients treated with activated protein C," Intensive Care Medicine, 2006;32(Supp 1):S178. Abstract 0681. Sales Jr J, Buchele GL, Ospina GA, Creteur J and Vincent JL, "Effects of activated protein C on the microvascular response to reactive hyperemia in patients with septic shock," Intensive Care Medicine, 2006;32(Supp 1):S290. Abstract 1125. Heyer L, Madadaki K, Rezlan E, Mateo J, Losser MR and Payen D, "Impact of time on systemic and local evaluation of perfusion/oxygenation during septic shock," Intensive Care Medicine, 2005;31(Supp 1):S16. Abstract 044. L'Her E, Goetghebeur D, Tonnelier J, Gut-Gobert C, Boumediene A, Renault A and Boles J, "Effects of recombinant human activated protein C on endothelial function during sepsis," Intensive Care Medicine, 2005;31(Supp 1):S43. Abstract 153. Carollo T, Creteur J, De Backer D and Vincent JL, "Microvascular response to reactive hyperemia is altered in septic patients," Intensive Care Medicine, 2004;30(Supp 1):S24. Abstract 074. Carollo T, Creteur J, De Backer D and Vincent JL, "Persistent altered microvascular reactivity is predictive of mortality in septic patients," Intensive Care Medicine, 2004;30(Supp 1):S163. Abstract 626. Pareznick R, Voga G, Knezevic R and Podbregar M, "Improvement of muscle tissue deoxygenation during stagnant ischemia in survivors of severe sepsis," Intensive Care Medicine, 2004;30(Supp 1):S144. Abstract 554.

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Informational Shocks, O-Label Prescribing and the Eects of Physician Detailing Bradley T. Shapiro∗ This Version September 1, 2015 (Preliminary Version. Comments Welcome.) Promotional strategies employed by pharmaceutical rms to convince physicians to prescribe their products are the subject of considerable regulatory scrutiny. In partic- ular, regulators worry that rms may use sales reps to try to convince physicians to