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10. Never open tester case except when replacing batteries. Do not SAFETY PRECAUTIONS
attempt any alteration of original specifications.
: Before use, read the following safety precautions
11. To ensure safety and maintain accuracy, calibrate and check the This instruction manual explains how to use your multimeter PM3 tester at least once a year.
safely. Before use, please read this manual thoroughly. After reading it, 12.The multimeter restricts in use in indoor.
keep it together with the product for reference to it when necessary.
The instruction given under the heading must be followed to prevent accidental burn or 1. Correct measurement may not be performed when using the electrical shock.
meter in the ferromagnetic / intense electric field such as places 1-1 Explanation of Warning Symbols
near a transformer, a high-current circuit, and a radio.
The meaning of the symbols used in this manual and attached to 2. The meter may malfunction or correct measurement may not be performed the product is as follows.
when measuring special waveform such as that of the inverter circuit.
Very important instruction for safe use.
Factory-preinstalled built-in battery The warning messages are intended to prevent accidents to operating personnel such as burn and electrical shock.
A battery for monitoring is preinstalled before shipping therefore it may The caution messages are intended to prevent damage to the instrument.
run down sooner than the battery life specified in the instruction manual.
battery for monitoring is a battery to inspect the functions DESCRIPTION OF FUNCTIONS
and specifications of the product. 1-3 Maximum Overload Protection Input
In the case of action or cancel that function as follows, do not Double insulation turn the function switch in the condition applied input. Protection voltage 1-2 Warning Instruction for safe use
1) Power switch and function switch DC500V, AC500V or Turn this switch to turn on and off the power and select the functions of To ensure that the meter is used safely, be sure to observe the Voltage and current Peak Max.700V instruction when using the instrument. 1. Never use meter on the electric circuit that exceed 3.6kVA.
: AC voltage is regulated by rms valus of sinusoidal wave.
2. Pay special attention when measuring the voltage AC 33Vrms This switch uses it for the switching of . In the case of the (46.7 V peak) or DC 70V or more to avoid injury. APPLICATION AND FEATURES
3. Never apply an input signal exceeding the maximum rating input value. 2-1 Application
3) Data hold switch 4. Never use meter for measuring the line connected with equipment This instrument is portable multimeter designated for measurement When this switch is pressed, the data display at that time continues (i.e. motors) that generates induced or surge voltage since it may of weak current circuit.
(DH lights on the display). When the measuring input changes, the INSTRUMENT CO.,LTD.
exceed the maximum allowable voltage.
2-2 Features
display will not change. When this switch is pressed again, the hold 5. Never use meter if the meter or test leads are damaged or broken.
This multimeter is very thin type. Body thickness is 8.5mm. Dempa Bldg., 4-4 Sotokanda 2-Chome status is canceled you can return to the measuring status. (DH on the 6. Never use uncased meter. Sharp contrast LCD with character 13.6mm high is employed, Chiyoda-ku, Tokyo, Japan display disappears.) 7. Always keep your fingers behind the finger guards on the probe and unit symbols is displayed on the screen of the LCD.
(DATA HOLD function does not work when measuring frequency.) when making measurements.
Addition function: Hz/Duty , Relative and Data Hold.
8. Be sure to disconnect the test pins from the circuit when changing the function.
Auto power off(15 min.) It is able to cancel it.
9. Never use meter with wet hands or in a damp environment.
The instrument has been designed in accordance with the safety standard IEC 1010-1.
(DC/AC 500V Max. CAT ) 4) Relative measurement switch (RELATIVE) This digital multimeter has 4000(5000) counts max. display, however, 5-2 Voltage, Hz/DUTY measurement
5-2-2 Hz/DUTY Measurements
Suppose that actual value is X1 when REL switch is pressed. Then, its range may change even less than 4000(5000) counts depending Maximum rating input value 60.00kHz / 99%
value of X-X1 is displayed for actual input value X after that. Each time on the using function or the measuring range.
1. Never apply an input signal exceeding the maximum rating input value.
pressing REL switch, value of X1 is updated. This function is exceptthe Hz/DUTY measurement mode.
2. Be sure to disconnect the test pins from the circuit when changing The setting and measurement (At the time of AC voltage input) of the In the case of use at the DCV and ACV function 5-1 Start-up Inspection
the function.
Hz/DUTY are possible at the DCV function too. However, we recommend In the case of canceled, please push the switch again. 3. Always keep your fingers behind the finger guards on the probe the use in the ACV function.
The measurement range is fixed to the range in the point that pushed when making measurements.
1.Be sure to pre-check the meter the switch. About measurement after this, the range is fixed. To 1) Applications: Measures frequency and duty of any circuit.
return to the auto range, please stop measurement once and set the 2) Measurement procedure 5-2-1 Voltage Measurement (DCV,ACV)
2.Do not use a damaged meter function again.
Set the function switch Maximum rating input value DC/AC 500V
and test leads.
Do not measure any signal that exceeds the maximum of current range.
at ACV function. Push the 3.Check continuity of test leads.
Hz/DUTY switch one time, In the case of use : Measures batteries and DC circuits.
4.When a battery exhaust mark and select the Hz function. When O.L is displayed, setting and cancellation are not possible.
: Measures sine-wave AC voltage as lighting voltages.
appears in the display, replace (The unit display is Hz display.) In the case of canceled, please push the switch again. 2) Measurement procedure the battery with a new one.
In the case of duty measurement, The resistance measurement range is fixed to the range in the point Set the function switch then push the Hz/DUTY switch that pushed the switch. About measurement after this, the range is one more time, and select fixed. To return to thmnge, please stop measurement once and To avoid danger of shock hazard, Apply the black test pin the duty function. set the function again.
do not use multimeter with to the negative potential (The unit display is % display.) In the case of use damage and repair the meter.
side of the circuit to measure Apply the red and black test pins to the circuit to measure.
In the case of canceled, please push the switch again. and the red test pin to the Read the value on the display.
The Capacitance measurement is auto range mode only. After canceled positive potential side.
After measurement, remove the red and black test pins from relative mode, it is possible measurement with the auto range. Exhaustion mark is Read the value on the display.
the circuit measured.
5) Hz/DUTY (Frequency/Duty)switch After measurement, remove With measuring terminals disconnected, display may overflow This switch uses it for the switching of Hz/DUTY. In the case of the Replace the battery.
the red and black test pins from or value may unsteadily fluctuate. There are not malfunctions.
mode change as Hz voltage measuring mode Please check again Input sensitivity varies according to frequency and wave-form. the circuit measured.
When it returns it to the voltage function after the Hz/DUTY Short the RED and Please refer to 8-2 Measurement Range and Accuracy. The display fluctuates when measurement the range is fixed automatically. (DCV function is It is only auto range mode. 400mV. ACV function is 4V.) Please stop measurement once to the test leads are removed. This is not malfunction.
When it returns it to the voltage function after the Hz/DUTY cancel the manual range. And please do measurement after the Since this instrument employs the means value system for its AC measurement the range is fixed automatically. (DCV function is function is set up again.
voltage measurement circuit, AC waveform other than sine wave 400mV. ACV function is 4V.) Please stop measurement once to 6) Auto power off may cause error.
cancel the manual range. And please do measurement after The power of the meter will automatically turned off after the beep if no operation In the AC4V ranges a figure of about 3 9 conuts will stay on even if the function is set up again.
is done for about 15 minutes. To reset the meter, press any button of the Stop using it and have no input signal is present.
DATA HOLD function does not work when measuring frequency.
RELATIVE, DATA HOLD, or Hz/DUTY. To cancel this function, press the SELECT it repaired.
The accuracy guaranteed frequency range is 40Hz to 400Hz.
The meter cannot measure frequency that does not go to and fro switch, or change the function switch from the OFF to a desired function while holding the SELECT switch pressed, and then release the SELECT switch after acouple of minutes. Set the function switch to OFF when meter is not in use.
note Non-marking may suggest that a battery be exhausted.
5-3 Resistance Measurement (
Replace the red and black test pins, make sure that the 2) Measurement procedure Make sure that the test leads are not cut, referring to the section.
displays the same as that when the test leads are released.
Set the function switch After measurement, release the red and black test pins from The dealer may conduct the calibration and inspection. For more Never apply voltage to the input terminal.
the object measured.
and select the function information, please contact the dealer.
6-3 How to Replace Battery
Judgment: When the items are normal, the diode is good.
by SELECT switch.
The reading may vary because of external inductance when The input terminals release voltage is about 1.5V.
Press the RELATIVE measuring high resistance value.
switch to make display 1. If the rear case is removed with input applied to the input terminals, 5-5 Checking Continuity (
show 00.00nF. (The REL you may get electrical shock. Before starting the work, always 1) Application: Resistance of resistors and circuits are measured.
make sure that no inputs is applied.
mark illuminates in the upper 2) Measuring ranges:400 2. Be sure to use the fuse is same rating so as to ensure safety and right area of the display.) Never apply voltage to the input terminal.
3) Measurement procedure performance of tester.
Apply the black red test pin Set the function switch at 3. When operators remove the rear case, do not touch the internal to capacitor.
1) Application: Checking the continuity of wiring and selecting wires.
parts or wire with hand.
Read the value on the display.
Apply the black red test 2) Measurement procedure After measurement, remove the red and black test pins from pin to measured circuit.
Set the function switch How to replace the battery the circuit measured.
Read the value on the Remove the rear case For measurement of 100nF or below, the display will not stabilize and select the function screw with a screwdriver.
After measurement, remove due to the influence of ambient noise and floating capacity.
by SELECT switch.
Remove the rear case.
the red and black test pins Necessarily please discharge the electric charge that was Apply the red and black Take out the battery and replace it with a from the circuit measured.
charged to the condenser before measurement. test pins to a circuit or If measurement is likely to be influenced by noise, shield the As the capacitance increases, the measuring time becomes Attach the rear case and fix it with the screw.
conductor to measure.
object to measure with negative potential (test lead black).
longer. (Example: approx. 5sec. at 10µ. Approx.45sec. at 150µ The continuity can be The input terminals release voltage is about 0.4V.
judged by whether the Set a battery with its polarities 5-4 Testing Diode (
facing in the correct directions.
buzzer sounds or not.
After measurement, release the red and black test pins from Never apply voltage to the input terminal.
6-4 Storage
the object measured.
1. This section is very important for safety. Read and understand the following The buzzer sounds when the resistance in a circuit to measure 1) Application: The quality of diodes is tested. instruction fully and maintain your instrument properly.
1. The panel and the case are not resistant to volatile solvent and is less than about 10 2) Measurement procedure 2. The instrument must be calibrated and inspected at least once a year to must not be cleaned with thinner or alcohol. For cleaning, use The input terminals release voltage is about 0.4V.
Set the function switch dry, soft cloth and wipe it lightly.
maintain the safety and accuracy.
5-6 Capacity Measurement (
2. The panel and the case are not resistant to heat. Do not place and select the function the instrument near heat-generating devices (such as a soldering iron) 6-1 Maintenance and inspection
by SELECT switch.
1. Never apply voltage to the input terminal.
3. Do not store the instrument in a place where it may be subjected 1. Appearance:Is the appearance not damaged by falling? Apply the black test pin to 2. This is not suitable for measurement of electrolytic condenser to vibration or from where it may fall.
2. Test leads: Is the cord of the test leads not damaged? the cathode of the diode and such as a large leakage condenser.
4. For storing the instrument, avoid hot, cold or humid places or places. Is the core wire not exposed at any place of the test leads? the red test pin to the anode.
If your instrument falls in any of the above items, do not use it and Make sure that the display 1) Application: Measures capacitance of capacity.
Under direct sunlight or where condensation is anticipated.
have it repaired or replace it with a new one.
shows a diode forward voltage drop.
Following the above instructions, store the instrument in good environment.
2) Repair during the warranty period: Safety: IEC 1010-1(EN61010-1) AFTER-SALE SERVICE
The failed meter will be repaired in accordance with the DC AC 500V: Designed to protection Class 7-1 Warranty and Provision
conditions stipulated in 7-1 Warranty and Provision.
*Accuracy in the case of sine Sanwa offers comprehensive warranty services to its end-users requirement of IEC 1010-1, Pollution degree .
3) Repair after the warranty period has expired: and to its product resellers. Under Sanwa's general warranty policy, In some cases, repair and transportation cost may become EMC: EN50081-1 (EN55022), EN50082-1 (EN61000-4-2) each instrument is warranted to be free from defects in higher than the price of the product. Please contact Sanwa EN50082-1 (EN61000-4-3), EN50082-1 (ENV50204) (0.7%rdg+5dgt) 9.999Hz 9.999kHz: 10Vrms 250Vrms.
workmanship or material under normal use for the period of one (1) authorized agent / service provider in advance.
60.00kHz: 40Vrms 100Vrms.
year from the date of purchase.
The minimum retention period of service functional parts is 6 Installation Category(Overvoltage Category) This warranty policy is valid within the country of purchase only, years after the discontinuation of manufacture. This retentionperiod is the repair warranty period. Please note, however, if About input sensitivity and and applied only to the product purchased from Sanwa authorized such functional parts become unavailable for reasons of agent or distributor.
discontinuation of manufacture, etc., the retention period may Sanwa reserves the right to inspect all warranty claims to determine Portable Equipment (Square wave DUTY 50% input) become shorter accordingly.
the extent to which the warranty policy shall apply. This warranty 8-2 Measurement Range and Accuracy
4) Precautions when sending the product to be repaired: 2.5V 0 to peak input: shall not apply to disposables batteries, or any product or parts, To ensure the safety of the product during transportation, Accuracy assurance range 23 RH MAX. No condensation.
6V 0 to peak input: which have been subject to one of the following causes: place the product in a box that is larger than the product 5 40V 0 to peak input: 1. A failure due to improper handling or use that deviates from times or more in volume and fill cushion materials fully and the instruction manual.
then clearly mark "Repair Product Enclosed" on the box Buzzer sounds at less than 10 2. A failure due to inadequate repair or modification by people surface. The cost of sending and returning the product shall be Open voltage: Approx. 0.4V other than Sanwa service personnel.
borne by the customer.
Open voltage: Approx 1.5V 3. A failure due to causes not attributable to this product such as 7-3 SANWA Website
fire, flood and other natural disaster.
4. Non-operation due to a discharged battery.
5. A failure or damage due to transportation, relocation or Accuracy in the case of sine wave.
dropping after the purchase.
8-1 General Specifications
Do not use the tester near places where strong electromagnetic 7-2 Repair
Measuring Method: case of sine wave. waves and trance are generated or strong electrical voltages are Customers are asked to provide the following information when Display: 4000 counts max.
*Frequency range: Range selection: Auto ranges requesting services: Accuracy calculation Over display: O.L display 1. Customer name, address, and contact information Polarity: Automatic selection (only *Open voltage: Approx. 0.4V 2. Description of problem Low Battery Indication: *The measuring current changes 3. Description of product configuration Sampling rate: Approx. 3 times/sec. according to the resistance Accuracy assurance temperature /humidity range: 5. Product Serial Number 80%RH max. No condensation.
6. Proof of Date-of-Purchase Operating temperature/humidity range: 1.0[mV](In a range of 99.0 7. Where you purchased the product 80%RH max. No condensation.
3[dgt] in the 400mV range corresponds to 0.3mV.
Please contact Sanwa authorized agent / distributor / service Storage temperature/humidity range: provider, listed in our website, in your country with above 70%RH max. No condensation.
*Accuracy was measured Environmental condition: Operating altitude <2000m, Pollution degree information. An instrument sent to Sanwa / agent / distributor after canceling display value Power supply: Coin type lithium battery CR2032 (3V), 1 pcs.
without those information will be returned to the customer.
(5.0%rdg+10dgt) by relative key.
Power consumption: Approx.6mW TYP. (at DCV) Specifications and external appearance of the product Battery life: Approx.150 hours at DCV described above may be revised for modification without 1) Prior to requesting repair, please check the following: Dimension and weight:108(H) 11.5(D)mm Approx.50g Capacity of the built-in battery, polarity of installation and Accessories: Instruction manual 1, Case holder 1 prior notice.
discontinuity of the test leads. DRAWING No.PM3 10-0907 2040 6017


PROCESSUS STRATEGIQUES : DES ELEMENTS CLES POUR COMPRENDRE L'APRES FUSION : LE CAS SANOFI AVENTIS Philippe REBIERE Professeur Associé (ICN Business School) Université Nancy 2 CEREFIGE Cahier de Recherche n°2010-02 Université Nancy 2 13 rue Maréchal Ney Téléphone : 03 54 50 35 80

Hm4370 474.476

British Journal of Haematology, 1999, 106, 474±476 Response to cladribine in previously treated patientswith chronic lymphocytic leukaemia identi®ed byex vivo assessment of drug sensitivity by DiSC assay ANDREW G. BOSANQUET,1 J. ADRIAN COPPLESTONE,2 STEPHEN A. N. JOHNSON,3 ALASTAIR G. SMITH,4 SARA J. POVEY,5JENNIFER A. ORCHARD6 AND DAVID G. OSCIER6 1Royal United Hospital, Bath, 2Derriford Hospital, Plymouth,