Slide 
Breast Cancer, Cancer and Surgery 
The Condition: 
Tumors in the breasts are not uncommon, especially after age 30. Tumors 
may be cancerous (malignant) or non-cancerous (benign). Approximately one 
in nine women will develop breast cancer. Early detection can be made with 
regular, manual self-examinations of the breasts, but not all tumors can be 
detected in this manner. Mammography (X-ray of the breast) can detect 
tumors that manual examination cannot. 
Tumors are often removed surgically and treatment of malignant tumors may involve 
surgery, radiotherapy, chemotherapy - or a combination of two or three of these 
Ovarian Tumor 
The Condition: 
Ovarian tumors may be malignant (cancerous) or benign (non-
cancerous). Tumors may be solid or a hollow sac (cysts). Cysts are 
sometimes filled with fluid and usually are the non-cancerous 
form of an ovarian tumor. Ovarian tumors are not all that 
uncommon and, if identified early, they can be removed surgically 
or with radiation treatments. 
Breast Cancer, Cancer and Surgery 
Breast Cancer, Cancer and Surgery 
Breast Cancer, Cancer and Surgery 
Fitness and Diving Issues: 
Cytotoxic drugs (chemotherapy) and radiation therapy can have unpleasant 
side effects such as nausea and vomiting, and a prolonged course of therapy 
can result in greatly decreased energy levels. This makes diving while 
experiencing such side effects inadvisable. Radiation and some 
chemotherapeutic drugs can cause pulmonary toxicity. 
An evaluation to establish the safety of a return to diving should include an 
assessment of the lung to ensure that damage likely to predispose the 
diver to pulmonary barotrauma (arterial gas embolism, pneumothorax or 
pneumomediastinum) is not present. 
Finally, before diving, healing must have occurred, and the surgeon must be 
satisfied that immersion in salt water will not contribute to wound 
infection. Strength, general fitness and well-being should be back to 
normal. The risk of infection, which may have increased temporarily during 
chemotherapy or radiotherapy, should have returned to normal levels. 
Pregnancy 
Description of Condition: 
Having a developing embryo or fetus in the body. Duration of pregnancy from 
conception to delivery is approximately 266 days/9 months. 
Fitness and Diving Issue: 
There is little scientific data available regarding diving while 
pregnant. Much of the available evidence is anecdotal. Laboratory 
studies are confined to animal research and the results are 
conflicting. Some retrospective survey type questionnaires have 
been performed but are limited by data interpretation. 
An issue to keep in mind is the risk of decompression illness to the mother due to the physiological changes which 
occur while pregnant. During pregnancy, maternal body fluid distribution is altered, and this redistribution 
decreases the exchange of dissolved gases in the central circulation. Theoretically, this fluid may be a site of 
nitrogen retention. Fluid retention during pregnancy may also cause nasopharyngeal swelling, which can lead to 
nose and ear stuffiness. In regards to diving, these may increase a pregnant woman's risk of ear or sinus 
squeezes. Pregnant women experiencing morning sickness, which could then couple with motion sickness from a 
rocking boat, may have to deal with nausea and vomiting during a dive. This is an unpleasant experience and could 
lead to more serious problems if the diver panics. 
Due to the limited data available and the uncertainty of the effects of diving on a fetus, diving 
represents an increased exposure for the risk of injury during pregnancy. There's a baseline incidence 
of injury including cases of decompression illness in diving. One must consider the effects on the fetus 
if the mother must undergo recompression treatment. 


Pregnancy 
Diving and Pregnancy Outcome 
Bangasser Survey 1978 - no increase defects 
Bolton Survey 1980 - 109 women who dived prior to pregnancy, 
69 stopped when pregnant higher rate of defects in groups who 
continued including two major cardiac anomalies multiple 
hemivertabrae, absent hand, VSD, coarctation, pyloric stenosis, 
birthmark - no major defects in group that stopped (but no 
higher than the general population and may be influenced by 
Turner Case Report 1982 
-twenty dives in 15 days, days post LMP 40-50 
-most less than 60 ft., three dives 100 ft., one 110 - one rather rapid ascent from 60 ft., three dives 
 100 ft., one 110 - one rather rapid ascent from 60 ft. 
-Sudafed also taken 
 -multiple anomalies 
-head circumference normal, development normal, karyotype, EMG, muscle biopsy normal 
 -mechanism of DCS injury - fetal embolism or bubbling. 
Please remember that one anecdotal report 
does not create a syndrome or disease ! 
Animal studies of DCS during pregnancy also have noted increases in cardiac 
malformations. If a woman dives inadvertently before pregnancy is diagnosed 
during the first trimester of pregnancy, acknowledging that a very limited 
amount of literature and experience exists, I suggest getting a second 
trimester ultrasound (sonogram) with emphasis on limb and spinal development 
and with good detailing of the cardiac structures and the configuration of the 
great vessels around the heart -- aorta, pulmonary arteries, etc. 
Return to Diving After Giving Birth 
 The Condition: 
Diving, like any other sport, requires a certain degree of 
conditioning and fitness. Divers who want to return to diving 
postpartum (after having a child) should follow the guidelines 
suggested for other sports and activities. 
 Fitness and Diving Issues: 
After a vaginal delivery, women can usually resume light to moderate activity within one to three 
weeks. This depends of several factors: prior level of conditioning; exercise and conditioning during 
pregnancy; pregnancy-related complications; postpartum fatigue; and anemia, if any. Women who have 
exercise regimens prior to pregnancy and birth generally resume exercise programs and sports 
participation in earnest at three to four weeks after giving birth. 
Obstetricians generally recommend avoiding sexual intercourse and immersion for 21 days 
postpartum. This allows the cervix to close, decreasing the risk of introducing infection 
into the genital tract. A good rule of thumb is to wait four weeks after delivery before 
returning to diving. 
Return to Diving After Giving Birth 
 Fitness and Diving Issues: 
After a cesarean delivery (often called a C-section, made via a surgical incision 
through the walls of the abdomen and uterus), wound-healing has to be included in 
the equation. Most obstetricians advise waiting at least four to six weeks after this 
kind of delivery before resuming full activity. Given the need to regain some 
measure of lost conditioning, coupled with wound healing, and the significant weight-
bearing load of carrying dive gear, it's advisable to wait at least eight weeks after 
a C-section before returning to diving. 
Any moderate or severe medical complication of pregnancy - such as twins, pre-term 
labor, hypertension or diabetes - may further delay return to diving. Prolonged bed 
rest in these cases may have led to profound deconditioning and loss of aerobic 
capacity and muscle mass. For women who have had deliveries with medical 
complications, a medical screening and clearance are advisable before they return to 
Additional Information: 
Caring for a newborn may interfere with a woman's attempts to recover her strength and 
stamina. Newborn care, characterized by poor sleep and fatigue, is a rigorous and demanding 
Return to Diving After Giving Birth 
 The Condition: 
A mother may choose to breast-feed her infant while maintaining an otherwise 
active life. This may continue for weeks or months, depending on the mother's 
Fitness and Diving Issues: 
Is it safe to scuba dive while breast-feeding? 
From the standpoint of the child, the mother's breast milk is not unduly affected. The 
nitrogen absorbed into the body tissues is a component of breathing compressed air or 
other gas mixes containing nitrogen. This form of nitrogen is an inert gas and plays no role in 
body metabolism. Although nitrogen accumulates in all of the tissues and fluids of the body, 
washout after a dive occurs quickly. Insignificant amounts of this nitrogen would be present 
in the mother's breast milk; there is, however, no risk of the infant accumulating this 
From the mother's standpoint, there is no reason for a woman who is breast-feeding 
her child to avoid diving, provided there is no infection or inflammation of the breast. 
 Beginning lactation
When the baby sucks, a hormone called oxytocin starts the milk flowing from the 
alveoli, through the ducts (milk canals) into the sacs (milk pools) behind the areola 
and finally into the baby's mouth 

Return to Diving After Giving Birth 
Breast Implants 
The Condition: 
Silicone and saline implants are used for cosmetic enhancement or 
augmentation of the normal breast size and shape of reconstruction, 
particularly after radical breast surgery for cancer or trauma. 
In one study, by Dr. Richard Vann, Vice President of Research at DAN, mammary (breast) 
implants were placed in the Duke University Medical Center hyperbaric chamber. The study did 
not simulate the implant in human tissue. Three types were tested: silicone-, saline-, and silicone-
saline-filled. In this experiment, the researchers simulated various depth / time profiles of 
recreational scuba diving. Here's what they found: There was an insignificant increase in bubble 
size (1 to 4 percent) in both saline and silicone gel implants, depending on the depth and duration 
of the dive. The least volume change occurred in the saline-filled implant, because nitrogen is less 
soluble in saline than silicone. 
The silicone-saline-filled type showed the greatest volume change. Bubble formation in implants 
led to a small volume increase, which is not likely to damage the implants or surrounding tissue. 
If gas bubbles do form in the implant, they resolve over time. 

Breast Implants 
Image displacement mammography 
views (also called Eklund views) are 
Standard mammography views are 
performed with the implant pushed 
 taken first.
back against the chest wall. The 
The breast and implant are 
compression paddle is applied to the 
 compressed
breast tissue, which is pulled forward. 
 with moderate force 
 Silicone vs. Saline: Types of Breast Implants 
There are two main types of breast implants, those that are saline-filled 
and those that are silicone gel-filled. Each of these breast implants can 
vary in shape, size, and shell texture. Some breast implants are pre-filled 
for a set size, and others are filled through a valve during surgery. Some 
types of breast implants even allow for filling adjustment after surgery for 
 size adjustment. 
Breast Implants 
Fitness and Diving Issues: 
Once sufficient time has passed after surgery, when the diver has 
resumed normal activities and there is no danger of infection, she may 
begin scuba diving. 
Breast implants do not pose a problem to diving from the standpoint of gas 
absorption or changes in size and are not a contraindication for participation 
in recreational scuba diving. 
Avoid buoyancy compensators with constrictive chest straps, which can put 
undue pressure on the seams and contribute to risk of rupture. 
Additional Considerations: Breast implants filled with saline are neutrally 
buoyant. Silicone implants are heavier than water, however, and they may 
alter buoyancy and attitude (trim) in the water, particularly if the implants 
are large. Appropriate training and appropriate adjustment of weights help 
overcome these difficulties. 
Menstruation During Diving Activities 
The Condition: 
Menstruation is the cyclic, physiologic discharge through the vagina of 
blood and mucosal tissues from the non-pregnant uterus. The cycle is 
controlled hormonally and usually occurs at approximately four-week 
intervals. Symptoms may include pain, fluid retention, abdominal 
cramping and backache. 
Fitness and Diving Issues: 
Are women at greater risk of experiencing decompression illness (DCI) while 
menstruating? Theoretically, it is possible that, because of fluid retention and tissue 
swelling, women are less able to get rid of dissolved nitrogen. This is, however, not 
definitively proven. 
One recent retrospective review of women divers (956 divers) with DCI found 
38 percent were menstruating at the time of their injury. Additionally, 85 
percent of those taking oral contraceptives were menstruating at the time of the 
accident. This suggests, but does not prove, that women taking oral 
contraceptives are at increased risk of decompression illness during 
menstruation. Therefore, it may be advisable for menstruating women to dive 
more conservatively, particularly if they are taking oral contraceptives. This 
could involve making fewer dives, shorter and shallower dives and making longer 
safety stops. Four other studies have provided evidence that women are at 
higher risk of DCI, and in one study of altitude bends, menses also appeared to 
be a risk factor for bends. 
Menstruation During Diving Activities 
Fitness and Diving Issues: 
Are women at an increased risk of shark attacks during menstruation? 
There are few reported shark attacks on women, and there are no data to 
support the belief that menstruating females are at an increased risk for 
shark attacks. The average blood lost during menstruation is small and 
occurs over several days. Also, it is known that many shark species are not 
attracted to the blood and other debris found in menstrual flow. 
In general, diving while menstruating does not seem to be a problem as long as normal, 
vigorous exercise does not increase the menstrual symptoms. As long as the menstrual 
cycle poses no other symptoms or discomforts that affect her health, there is no 
reason that a menstruating female should not dive. However, based upon available 
data, it may be prudent for women taking oral contraceptives, particularly if they are 
menstruating, to reduce their dive exposure (depth, bottom time or number of dives 

Premenstrual Syndrome 
The Condition: 
Premenstrual Syndrome, or PMS, is a group of poorly understood and poorly 
defined psychophysiological symptoms experienced by many women (25-50 
percent of women) at the end of the menstrual cycle, just prior to the 
PMS symptoms include mood swings, irritability, decreased mental alertness, 
tension, fatigue, depression, headaches, bloating, swelling, breast tenderness, joint 
pain and food cravings. Severe premenstrual syndrome has been found to 
exacerbate underlying emotional disorders. Although progesterone is used in some 
cases, no consistent, simple treatments are available. 
Fitness and Diving Issues: 
Research has shown that accidents in general are more common 
among women during PMS. If women suffer from premenstrual 
syndrome, it may be wise to dive conservatively during this time. 
There is no scientific evidence, however, that they are more 
susceptible to decompression illness or dive injuries / accidents. 
Also, individuals with evidence of depression or antisocial tendencies should 
be evaluated for their fitness to participate in diving: they may pose a risk 
to themselves or a dive buddy. 
Oral Birth Control 
Description of Condition: 
An effective and widely used method of preventing pregnancy. 
There are several types of pills available and most contain a 
combination of synthetic estrogen-like and progesterone-like 
substances. These substances prevent the rise in luteinizing 
hormone, which leads to ovulation. Also, oral contraceptives 
thicken and chemically alter the cervical mucus, making the 
uterine endometrium less receptive to sperm. 
Possible side effects of oral contraceptives during the initial therapy include nausea, 
vomiting, fluid retention, headaches and dizziness. Oral contraceptives may also be 
associated with an increase in blood pressure and an increased risk of thromboembolic 
disorders (development of clot-like vein occlusions, which can lead to an emboli). 
Fitness and Diving Issue: 
It has been suggested that oral contraceptives may increase a diver's susceptibly to DCS because of the 
hormonal changes, which may reduce venous tone and increase water retention. This could affect circulation 
and theoretically cause the blood to "sludge," which may interfere with the elimination of nitrogen from the 
body. To date, no research has found evidence to support this belief. 
In fact, unless oral contraceptives pose a clinical problem for women, there is no data to show that their 
 use during recreational scuba diving is a contraindication. 
Oral Birth Control 
Additional Considerations: 
But what about contraception -- are there any specific hazards attached 
to contraceptive methodologies which women and their consorts should 
consider. Current thinking is that oral contraceptives do not impose any 
increased risks on women divers. Most oral contraceptives used in the 
USA carry a three- to four-fold increase risk of spontaneous non-fatal 
thrombotic events, while pills containing desogestre (and gestodene, a 
progestin commonly used in pills in the UK and other European countries 
but not in the US) may carry a 6-8 fold increase in risk compared to no pill 
use. When considering this increased risk of thrombosis, hyperbaric 
researchers have been speculated that oral contraceptive use might 
increase the likelihood of developing DCS or exacerbate the extent or 
severity of tissue injury by promoting more rapid and profound activation 
of the clotting cascade after a gas accident. 
No animal studies have been done which support this hypothesis. On the contrary, one experiment of 
DCS was done with pigs wherein half of the pigs were premedicated with oral contraceptives and then 
subjected to chamber profiles inducing DCS injuries. The study found that extent of injuries was 
identical in the treated and control pigs. No human epidemiologic surveys of sufficient sample size to 
offer any information that is clinically useful have ever been done. 
Recently the gynecologic literature has suggested that 50 percent of 
thromboembolic on oral contaceptives may be due to interactions of the medication 
with inherited clotting disorders, the most common abnormality being a protein 
substitution in the chain of molecules forming clotting factor V. This substitution 
renders factor V resistant to cleavage by activated protein C which would 
inactivate its pro thrombotic action. The resultant disorder is called activated 
protein C resistance. 

Oral Birth Control 
Additional Considerations: 
Underlying coagulation defects have been implicated as increasing the 
risk of DCS. As a matter of fact, heritable clotting disorders have been 
implicated in idiopathic aseptic necrosis of the femoral head and a host of 
other vascular complications. Those populations with a high incidence of 
factor V Leiden mutation, the most common genotype responsible for this 
coagulation defect, should be alert to and aware of clotting disorders. 
Think of them when you encounter the unexpected, undeserved "hit" that 
just seems too severe for the dive profiles when reviewing the diver's log 
and history. And, of course, ask about oral contraceptive use. 
Contraceptives Fact Sheet 
Progesterone only pills, and long acting contraceptives (Norplant and Depo Provera) 
The progestins, similar to those used in injectable contraceptives, all 
progesterone mini pills, and implants, have effects on inflammatory cells. High 
doses of progesterone have been found to help to stabilize cell membranes, and 
thereby limit inflammatory response to injury. Women with sickle cell anemia on 
high doses of progesterone have fewer and less severe sickle cell episodes. If 
progestins act to limit inflammation, it might be postulated that they could help 
limit the damage caused by the inflammatory processes that follow tissue 
hypoxia in gas accidents. If true, we also might speculate that long acting or high 
dose progestins might be the contraceptive of choice for women divers. 
Barriers and Spermicides 
Occasional questions arise about the possibility that the efficacy of barrier methods could be 
reduced by immersion and dilution of the spermicidal agents if water washes in and out of the 
vagina. The amount of flushing action in a wet suit is probably minimal; and obviously, is not a 
consideration for dry suits. 
Intrauterine contraceptive devices pose no hazard for the 
female diver. Menstrual flow is increased in amount and 
duration of flow. This can be a great inconvenience if a woman 
is diving in a remote locale or on a boat with no sanitary 
facilities or privacy. 
Description of Condition: 
To date, we have not had significant pool of women who: 
- are post menopausal and at risk of osteoporosis 
(menopause average at 50, osteopenia at 60-65, and 
fractures starting at 70-75) 
- have a significant diving experience including appropriate 
number of dives at profound depth which put them at risk for 
- therefore, we have no data on coincident osteoporosis and osteonecrosis in women at risk (or men for that matter). 
Fitness and Diving Issue: 
The pathophysiologic mechanisms leading to osteoporosis and osteonecrosis are 
different. Osteoporosis results from decreases in osteoblast activity and 
relative increase of osteoclast activity, resulting in bone resorption and 
demineralization. The infarction of the microcirculation of bone is the 
triggering mechanism for osteonecrosis. 
Women are at increased risk for osteoporosis given that their overall lifetime 
peak bone mass is lower than men and that the loss of estrogen during 
menopause, greatly accelerates the rate of bone demineralization 
All we can say at this point is that women should dive as conservatively as possible, thereby 
trying to minimize their risks of osteonecrosis, so as not to impose this bone damaging 
disease on top of their already increased risk of fracture due to Type I estrogen dependent 
Source: http://www.nurkopedia.pl/images/e/ec/Women_and_diving.pdf
   Prescribing Information  RelaxaTM  Polyethylene Glycol 3350  Powder for Oral Solution  Red Leaf Medical Inc.  Date of Preparation:  12 – 4055 Sladeview Crescent  Date of Revision:  <March 07, 2014>   Submission Control No: 126786   RelaxaTM Package Insert  Page 1 of 13  Table of Contents   RelaxaTM Package Insert 
  
   For BROCK BIOLOGY OF MICROORGANISMS, THIRTEENTH EDITION Michael T. Madigan, John M. Martinko, David A. Stahl, David P. Clark Chapter 26 Microbial Growth  Lectures by John ZamoraMiddle Tennessee State University © 2012 Pearson Education, Inc. Microbial Growth Control • Sterilization – The killing or removal of all viable organisms