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e-mail: ahmadloo@sums.ac.ir J Babol Univ Med Sci; 11(3); Aug-Sep 2009 The Effect of Sucralfate in Prevention ; N. Ahmadloo, et al RTOG/ EORTC
Kneebone, Martenson J Babol Univ Med Sci; 11(3); Aug-Sep 2009 The Effect of Sucralfate in Prevention ; N. Ahmadloo, et al The Effect of Sucralfate in Prevention of Radiation- Induced
Acute Proctitis
N. Ahmadloo (MD) 1, L. Kasraian (MD) 2, M. Mohammadian Panah (MD) 1 ,
S. Omidvari (MD) 1, A. Mosalaei (MD) 3
1. Associate Professor of Radiotherapy & Oncology, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran 2. Assistant Professor of Social Medicine, Member of Blood Transfusion Research Center of Tehran, Shiraz University of Medical Sciences, Shiraz, Iran 3. Professor of Radiotherapy & Oncology, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran Received: Dec 2nd 2008, Revised: Feb 18th 2009, Accepted: May 12th 2009.
ABSTRACT
BACKGROUND AND OBJECTIVE: Acute proctitis is a common, disturbing side effect of pelvic irradiation that
might interrupt treatment. To decrease or prevention of these side effects many drugs were used but no effective treatment was found. The aim of this study was to evaluate the efficacy of sucralfate for possible reduction of radiation-induced lower GI toxicities. METHODS: In this clinical trial study 100 patients that required curative pelvic radiation therapy were randomly
divided into two groups. Group one received 3g oral sucralfate and group two received placebo as control. All patients were given at least 50 Gy external-beam irradiation. Their bowel symptoms that include diarrhea, abdominal pain or distention, mucous or bloody discharge, obstruction or perforation were scored according to the RTOG/EORTC acute toxicity criteria. Desquamation and duration of treatment interruption were studied in both FINDINGS: From cases, there were 49 cases in group one and 47 cases in group two and 4 cases were excluded
from study. The two groups were statistically the same according to sex, age, anatomopathology and radiation therapy parameters. Comparing acute lower GI toxicities, desquamation and duration of treatment interruption, there were no statistically significant differences between the two groups. No acute lower GI toxicities were seen in 18 cases from group one and 10 cases from group two. No grade 4 lower GI toxicities were seen in patients. CONCLUSION: In our study, there was no clinical evidence that oral sucralfate ameliorates radiation-induced
proctitis. Therefore, sucralfate as a routine prophylactic agent is not suggested in pelvic radiation therapy and further investigations are generally needed to find out the efficacy of sucralfate in radiation-induced GI toxicities. KEY WORDS: Sucralfate, Pelvic radiotherapy, Proctitis.
Corresponding Author;
Address: Radiotherapy & Oncology, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran
E-mail: mohpanah@sums.ac.ir
References
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