Si1211_antioxidants_hickman_fcx.indd
BY SZILVIA HICKMAN
NATURAL SKIN CARE
to prevent damage to the body
diminishes the skin's structural support and decreases
ANTIOXIDANTS WORK before it actually happens.
its elasticity, resilience and suppleness, leads to
They protect and nurture cells naturally, combating
inflammation, and is the source of liver spots and poor
disease and promoting good health. Antioxidants
skin condition. In addition to being the main culprit of
come in many forms, including minerals, enzymes
wrinkles, free radicals, in essence, accelerate the aging
and vitamins. Vitamins and minerals with antioxidant
process. Studies have shown antioxidants stop this
properties are called nutrient antioxidants. The
cellular chain reaction of oxidation by neutralizing free
family of naturally formed components protects cells
from free radicals, which are highly charged oxygen molecules with unpaired electrons that attempt to
obtain electrons from other molecules.
Antioxidants can improve cell function; increase
Free radicals are formed naturally in the body,
collagen production; improve elasticity; create
but their production is increased by factors such
healthier, younger skin cells; and reduce sun damage
as smoking, sun damage, stress and toxins like
. but the improvement takes time. Like a healthy diet,
air pollution and asbestos. The resulting damage
the more potent the antioxidants used, the healthier the
November 2012 Skin Inc.
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Reproduction in English or any other language of all or part of this article is strictly prohibited. 2012 Al ured Business Media.
results. Black currants, cherries,
OPCs are a special family of polyphenols
cantaloupe, grapes, blueberries,
(bioflavonoids) capable of renewing the
blackberries, cranberries, peppers
most important building blocks—such as
and spinach are among a growing
collagen and elastin fibers—of every part
variety of foods found to contain
of the human body, including the skin. In
surprisingly high levels of disease-fighting
the connective tissue, OPCs bind to collagen
antioxidant compounds, according to a U.S.
to maintain and even restore the cross-links, hence the
Department of Agriculture (USDA) study published in
flexibility of these essential proteins.2 Grape seeds are
the
Journal of Agricultural and Food Chemistry in 2004.
one of the richest known sources of OPCs. Red grapes
This study is one of the largest, most comprehensive
also contain a natural plant antibody, resveratrol,
analyses to date of the antioxidant content of
which has the effects of an antioxidant.
commonly consumed foods.
Vitamin E is a high-potency antioxidant that helps
As an ultimate superfruit, the grape's abundance of
improve circulation and repair tissue, and is one of the
polyphenols with antioxidant and anti-inflammatory
most efficient chain-breaking antioxidants available. It
properties not only keeps blood vessels resilient, but
helps prevent cell damage by inhibiting the formation
also boosts the skin and body's resistance against
of free radicals. Vitamin E helps retard aging and may
disease. Researchers have found, in particular, that the
help prevent age spots. Alpha-tocopherol—a form of
skin and seeds of grapes contain large concentrations
vitamin E—helps protect enzymes, such as glutathione
of compounds that have a positive effect on health,
peroxidase 4, which is known to act against cancerous
such as bioflavonoids, including quercetin, which
cell activity.3 Alpha-tocopherol is the most common
has an antioxidant and anti-inflammatory effect, and
antioxidant source from food. Some of the natural
oligomeric proanthocyanidins (OPCs), incredibly
sources of vitamin E are nut oils, corn oil, tomatoes,
effective chemicals in neutralizing free radicals.2
spinach and peppers.
November 2012 Skin Inc.
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Free Radical-fighting Facial
In addition to helping fortify cells against free
Duration: 60 minutes
radicals, vitamins A and C also encourage cell and
Contraindications: Clients who are allergic to the
tissue growth, helping the body to repair itself.
ingredients in this facial and those who use tretinoin
Vitamin C is a potent antioxidant that plays a major
should not receive this treatment.
role in many physical functions, including collagen production, immune function, cell growth and cancer
Equipment and supplies needed:
prevention. One of the most potent natural sources
of vitamin C is rose hips, and carrots are a primary
source for vitamin A.
TOPICAL CARE
Antioxidants can come from healthy eating, but only
Cleansing milk containing grape seed and OPCs
a small percentage of consumed antioxidants actually reach the skin, because they primarily act internally in
Toner infused with natural vitamins and minerals
the body. However, products containing antioxidants
Exfoliator containing natural ingredients, such as corn
can be used to directly affect the skin.4 Antioxidants
meal, sulphur or enzymes
can be found in everything from masks, moisturizers
Mask with bioflavonoids, polyphenols and pectins
and cleansers to anti-wrinkle and anti-aging creams,
Antioxidant-rich serum
serums and lotions. Topical applications should contain a potent assortment of stable antioxidants to
Moisturizer formulated with OPCs
interrupt free-radical damage. Effective antioxidants
Physical, biochemical sunscreen
for the skin range from green tea, grape extract or vitamin C to idebenone, epigallocatechin-3-gallate or
Step 1: Have the client complete a client intake
superoxide dismutase. Certain phytochemicals, such
form in order to evaluate her needs. Lead her to
as lycopenes and anthocyanins, and zoochemicals,
the treatment room and ask her to put on the
such as conjugated linoleic acid, are called non-nutrient
wrap and get under the sheets, face up. Leave the
antioxidants. Selenium, copper and zinc are some of
room to allow for her privacy, and return in a few
the most common antioxidant minerals. They can be
absorbed by plants and can appear as micronutrients in
Step 2: Apply warm towels to the décolleté and the
botanical ingredients grown in rich soils that are used
face to prepare the pores. Be sure to include the
in skin care products. Antioxidant enzymes include catalase, superoxide dismutase and various peroxidases.
neck in your treatment; it is often neglected and,
The more the better—the skin does better with a
as a result, it shows aging faster.
cocktail of effective antioxidants.
Step 3: Cleanse the skin with a cleansing milk
Although most antioxidants can be used as a
containing antioxidant-rich grape seed and OPCs.
single agent, studies have shown that they work best
Apply a small amount of cleanser over the entire
as a team.5 Take a look at nature, for example, and
face and neck area, and, using your fingertips,
you'll see that plants, including fruits and vegetables,
massage it in gently for 30–60 seconds, moving in
contain many different phytonutrients—the source
circular motions. Then, wipe it off with a warm,
of antioxidants. These phytonutrients serve various
damp face towel. Repeat this step if necessary,
functions in plants—some protect the plant from UV
or perform a second step cleansing with a deep
radiation while others protect it from insects—all of
cleansing product.
which work together to protect the plant's vitality. This reinforces the idea that antioxidants are designed by
Step 4: Next, apply a toner to the skin with a gauze
nature to work together.
cloth or spritz the face lightly to remove any excess product and to balance the natural pH of
AT THE SPA
the skin. Use a toner infused with natural vitamins
For clients who want a natural approach to smooth,
and minerals to rejuvenate the skin, evening out
healthy skin, incorporate antioxidants into their skin
the pores and readying the skin for better moisture
care routine for a positive effect. Vitamins A, C and E
and the mineral selenium—a nutrient that functions
Continued on Page 67
as cofactor for the reduction of antioxidant enzymes—are believed to be particularly helpful in skin care.
November 2012 Skin Inc.
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Continued from Page 66
Step 5: After the skin is cleansed, gently apply a thin
layer of exfoliator to the skin, leaving it on for 15 minutes. Look for an exfoliator containing
Selenium is the only mineral that functions as an
natural ingredients, such as cornmeal, sulfur or
antioxidant. Skin care products containing selenium
enzymes that work to remove dead keratin cells,
help improve the skin's elasticity, fight acne, prevent free
stimulate blood circulation and soften the skin.
radicals from damaging collagen and elastin in the skin, and reduce the effects of aging.
Step 6: Apply a mask to revive collagen fibers. Seek
Coenzyme Q10 is an antioxidant enzyme that helps
out masks that are formulated to bring more
to protect cells from damage. CoQ10 is needed to create
oxygen to the skin as they detoxify, reduce
energy in a cell and, as cells age and are damaged, levels
inflammation and stimulate cell reproduction.
of CoQ10 decrease, as well. Studies have shown that
Most masks should remain on the face 20 minutes
CoQ10 can penetrate the skin, reduce wrinkle depth and
for maximum results, or until dry. Natural key
prevent sun damage.6
ingredients to look for include bioflavonoids,
In addition to helping fortify cells against free
polyphenols and pectins.
radicals, vitamins A and C also encourage cell and tissue growth, helping the body to repair itself. This is
Step 7: Apply an antioxidant-rich serum, such as one
very helpful to the skin, which is constantly shedding
containing grape seed oil. This is ideal for fighting
and re-growing cells. For this reason, any antioxidants
free radicals, and the decreased elasticity that is
that protect cells and encourage cell growth could be
associated with aging, dehydrated or tired skin.
helpful in an anti-aging regimen, because they may
Grape seed oil is packed with antioxidants, helps
help fight fine lines and wrinkles
firm the skin by stimulating collagen production,
When antioxidants are used on the skin, even if
and serves as a key ingredient in hydrating,
they don't penetrate beyond the upper layers, they
softening and leaving the skin silky smooth.
can help to stop or slow the process of oxidation caused by free radicals and keep the cell membranes more stable.4 The problem with some antioxidants is that they themselves are not stable, so, as soon as they are exposed to oxygen or light, they break down. The trick is to use antioxidants that are stable, effective and nonirritating in adequate concentrations to exert an effect. Reputable skin care lines do contain stable antioxidants. Personal care products are typically preserved by natural or synthetic preservatives that provide a well-tested and well-determined shelf life to the products. This shelf life is the base of the warranties that manufacturers and distributors provide on their products. It is advised to discontinue the use of products after their shelf life expires, because the stability of antioxidants may be
Step 8: Apply a thin layer of moisturizer to the skin.
compromised. Also, read ingredient lists carefully and
Use a moisturizer formulated with OPCs to help
select products that have a treatment manual with
renew the collagen fibers, and regenerate the
detailed information on all ingredients. Examples of
epidermis and the connective tissues. Look for
antioxidants used often in skin care products are grape
products with grape seed, red grape skin and
seed oil, and vitamins A, C, and E.
pine bark, which are known to be the three
The market for anti-aging products for appearance
most potent OPC sources. Skin will feel toned,
enhancement in the United States is expected to reach
smoothed and strengthened by the antioxidant
more than $5 billion by 2015, according to a report
ingredients delivered from each step.
by the Global Industry Analysts, Inc. And while a burgeoning baby boomer population has largely fueled
Step 9: The final step in the natural free
the growth, other factors contributing to the anti-aging
radical-fighting facial is sun protection. Use a
surge are an expanded interest among those ages 25–30.
sunscreen with physical—such as non-nano
The United States and Europe are leading the anti-aging
titanium dioxide—and biochemical—
market with a 62.8% share, and future growth is only
antioxidant-rich herbs and vegetables including
expected to continue within the cosmeceutical category
tomato and carrot—sunscreen effects.
at an estimated annual rate of 10%.
www.SkinInc.com November 2012 Skin Inc.
With so much growth potential and so much
antioxidants provides the skin with an arsenal to deflect
consumer interest to lead healthier lives, there has
the assault and minimize the damage created by
never been a better time than now to incorporate a
natural treatment offering that relies on the powerful benefits that only antioxidants can deliver. Antioxidant
facials, massages and body wraps are just a few ways
1. B Hal iwel , R Aeschbach, J Loliger and OI Aruoma, The characterization
to add this component to your spa menu.
of antioxidants
Food and Chemical Toxicology 33 7 601–617 (1995)
2. J Souquet, V Cheynier, F Brossaud and M Moutounet, Polymeric
proanthocyanidins from grape skins,
Phytochemistry 43 2 509–512 (1996)
3. R Brigelius-Flohé and MG Traber, Vitamin E: Function and metabolism,
After providing a client with a customized skin
The FASEB Journal 13 10 1145–1155 (1999)
analysis, be sure to offer a list of products used during
4. AI Bogdan and L Baumann, Antioxidants used in skin care formulations,
the treatment, with a description of each one's benefits
Skin Therapy Lett 13 7 5–9 (2008)
and active ingredients, and work with clients to ensure
5. L Packer,
The Antioxidant Miracle Wiley (1999)
their purchases from your retail area will support their
6. HN Bhagavan, Hemmi and RK Chopra, Coenzyme Q10: absorption, tissue
uptake, metabolism and pharmacokinetics,
Free Radical Research 40 5
in-spa care. Today's consumers are more and more
ingredient savvy and want to know exactly what is in their skin care products; so, be sure you know the products you are recommending. In between services,
Szilvia Hickman is senior vice president
educate your clients on a customized treatment plan
of Szép Élet, exclusive distributor of ilike
that will help to maintain the services they received
organic skin care and Purée Organics.
at your facility. Daily replenishment of topical
November 2012 Skin Inc.
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Source: http://testing13.oditech.hu/wp-content/uploads/2012/10/Antioxidants_Hickman_article_SkinIncNov12-2012.pdf
Systems Chemistry, May 26th – 30th, 2008, Bozen, Italy The Chemistry of Signal Transduction in Harald Lanig and Timothy Clark Na¨gelsbachstraße 25, 90152 Erlangen, Germany Received: 28th October 2008 / Published: 16th March 2009 Signal transduction proteins in biological systems must be very flexibleto undergo the allosteric changes necessary for their function. It iscurrent practice to investigate the modes of action of these systemsby X-ray spectroscopy of the different states trapped as crystals. Un-fortunately, the forces acting on the proteins by packing effects maylead to distortions comparable to the changes that occur during theallosteric movements. This makes it questionable as to whether X-raystructures can be used to deduce induction mechanisms. In this work,we show for DNA-binding tetracycline repressor proteins that molecu-lar dynamics simulations offer an interesting alternative for determin-ing the induction state and possible mechanisms switching betweenthem. Based on data sampled for different repressor classes with sev-eral force field parameter sets, we show that MD simulations haveconvincing advantages over the analysis of static structures influencedby crystal packing.
Al Khalifah et al. Systematic Reviews (2015) 4:125 DOI 10.1186/s13643-015-0105-4 The effectiveness and safety of treatmentsused for polycystic ovarian syndromemanagement in adolescents: a systematicreview and network meta-analysis protocol Reem A. Al Khalifah1,2,3, Iván D. Flórez1,4* Brittany Dennis1, Binod Neupane1, Lehana Thabane1,5,6and Ereny Bassilious2 Background: Polycystic ovarian syndrome (PCOS) is a common reproductive endocrine disease that is seen amongadolescent women. Currently, there is limited evidence to support treatment options leading to considerable variationin practice among healthcare specialists. The objective of this study is to review and synthesize all the available evidenceon treatment options for PCOS among adolescent women.